Accedi

Chonnam National University

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Wonbin Park^*1, Mihyeon Bae^*1, Minseon Hwang¹, Jinah Jang², Dong-Woo Cho¹, Hee-Gyeong Yi^1,3

¹Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), ²Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), ³Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University

Hypoxia is a hallmark of tumor microenvironment and plays a crucial role in cancer progression. This article describes the fabrication process of a hypoxic cancer-on-a-chip based on 3D cell-printing technology to recapitulate a hypoxia-related pathology of cancer.

Bioengineering

High-Throughput Bioprinting Method for Modeling Vascular Permeability in Standard Six-well Plates with Size and Pattern Flexibility

Ashfaq Ahmad^1,2, Mst Zobaida Akter^1,2, Seo-Yeon Kim^1,2, Yeong-Jin Choi^3,4, Hee-Gyeong Yi^1,2

¹Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences (CALS), Chonnam National University, ²Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, ³Advanced Bio and Healthcare Materials Research Division, Korea Institute of Materials Science (KIMS), ⁴Advanced Materials Engineering, Korea National University of Science and Technology (UST)

We present a protocol for high-throughput production of vascular channels with flexible sizes and desired patterns on a standard six-well plate using 3D bioprinting technology, referred to as vessels-on-a-plate (VOP). This platform has the potential to advance the development of therapeutics for the disorders associated with compromised endothelium.