A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin NebulizationDingyun Song 1,2, Yicong Chen 1,3, Xin Wang 1,4, Xueying Chen 1,2, Shuwei Gao 1,3, Wenxiu Xu 1,3, Shengnan Yang 5, Zai Wang 6, Liang Peng 7, Huaping Dai 1,2
1Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, 2Graduate School of Peking Union Medical College, Chinese Academy of Medical Science and Peking Union Medical College, 3Capital Medical University, 4Beijing University of Chinese Medicine, 5Tianjin Chest Hospital, 6Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, 7Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital
Various animal models of pulmonary fibrosis have been established using bleomycin to clarify the pathogenesis of pulmonary fibrosis and find new drug targets. However, most pulmonary fibrosis models targeting lung tissue have uneven drug administration. Here, we propose a model of uniform pulmonary fibrosis induced by nasal bleomycin nebulization.
