Stress-induced Antibiotic Susceptibility Testing on a ChipMaxim Kalashnikov 1, Jennifer Campbell 1, Jean C. Lee 2, Andre Sharon 1,3, Alexis F. Sauer-Budge 1,4
1Fraunhofer USA Center for Manufacturing Innovation, 2Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 3Department of Mechanical Engineering, Boston University, 4Department of Biomedical Engineering, Boston University
We have developed a microfluidic platform for rapid antibiotic susceptibility testing. Fluid is passed at high speeds over bacteria immobilized on the bottom of a microfluidic channel. In the presence of stress and antibiotic, susceptible strains of bacteria die rapidly. However, resistant bacteria can survive these stressful conditions.
