In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in MiceStefanie Fischer *1, Christian Engelmann *2, Karl-Heinz Herrmann 3, Jürgen R. Reichenbach 3, Otto W. Witte 1, Falk Weih 2, Alexandra Kretz 1, Ronny Haenold 2
1Hans Berger Department of Neurology, Jena University Hospital, 2Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, 3Institute of Diagnostic and Interventional Radiology, Medical Physics Group, Jena University Hospital
This video illustrates a method, using a clinical 3 T scanner, for contrast-enhanced MR imaging of the naïve mouse visual projection and for repetitive and longitudinal in vivo studies of optic nerve degeneration associated with acute optic nerve crush injury and chronic optic nerve degeneration in knock-out mice (p50KO).
