Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical ProductionEric Schopf *1, Christopher M. Waldmann *2,3, Jeffrey Collins 2,4, Christopher Drake 1, Roger Slavik 2,3, R. Michael van Dam 2,4
1SOFIE, 2Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 3Ahmanson Translational Imaging Division, University of California, Los Angeles (UCLA), 4Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA)
Positron-emission tomography (PET) imaging sites that are involved in multiple early clinical research trials need robust and versatile radiotracer manufacturing capabilities. Using the radiotracer [18F]Clofarabine as an example, we illustrate how to automate the synthesis of a radiotracer using a flexible, cassette-based radiosynthesizer and validate the synthesis for clinical use.
