Evaluation and Manipulation of Neural Activity Using Two-Photon Holographic MicroscopyDaisuke Kato 1,2, Xiangyu Quan 3, Yuta Tanisumi 1,2, Zhongtian Guo 1,2, Mitsuhiro Morita 4, Tetsuya Takiguchi 5, Osamu Matoba 6, Hiroaki Wake 1,2,6
1Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, 2Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 3Department of System Science, Kobe University Graduate School of System Informatics, 4Department of Biology, Graduate School of Sciences, Kobe University, 5Department of Information Science, Kobe University Graduate School of System Informatics, 6Center of Optical Scattering Image Science, Kobe University
We developed a two-photon holographic microscope that can visualize, assess, and manipulate neural activity using high spatiotemporal resolution, with the aim of elucidating the pathogenesis of neuropsychiatric disorders that are associated with abnormal neural activity.
