Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid VariantsKleopatra Rapti 1,2, Olena Maiakovska 1,2, Jonas Becker 1,2, Joanna Szumska 1,2, Margarita Zayas 1,2, Felix Bubeck 1,2, Jixin Liu 1,2, Emma Gerstmann 1,2, Chiara Krämer 1,2, Ellen Wiedtke 1,2, Dirk Grimm 1,2,3,4,5
1Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, 2BioQuant Center, BQ0030, University of Heidelberg, 3Cluster of Excellence CellNetworks, 4German Center for Infection Research (DZIF), 5German Center for Cardiovascular Research (DZHK)
AAV peptide display library generation and subsequent validation through the barcoding of candidates with novel properties for the creation of next-generation AAVs.
