Closure of Laparotomy and Postoperative Assessment
4:58
Aortic Dissection and Staining
5:40
Results: Efficiency of Endothelial Denudation and Reproducibility and Denudation Injury
7:28
Conclusion
Trascrizione
The overall goal of this surgical procedure is to create a highly reproducible murine model of arterial denudation injury in the infrarenal abdominal aorta to examine arterial re-endothelialization. This method can help answer key questions in vas
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Understanding the cellular and molecular mechanisms of re-endothelialization following arterial denudation injury is of paramount importance in preventing thrombosis and restenosis of arteries. Here we describe a protocol for reproducible arterial denudation injury of the infrarenal abdominal aorta. The procedure was developed to investigate the underlying mechanisms that regulate endothelial regeneration using mouse models.