Cleo Kontoravdi

Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography.

Application of global sensitivity analysis to determine goals for design of experiments: an example study on antibody-producing cell cultures.

Modeling amino acid metabolism in mammalian cells-toward the development of a model library.

Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns.

A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus.

Metabolic network reconstruction: advances in in silico interpretation of analytical information.

Genome-based kinetic modeling of cytosolic glucose metabolism in industrially relevant cell lines: Saccharomyces cerevisiae and Chinese hamster ovary cells.

The role of ER stress-induced apoptosis in neurodegeneration.

Quantification of intracellular nucleotide sugars and formulation of a mathematical model for prediction of their metabolism.

In situ monitoring of intracellular glucose and glutamine in CHO cell culture.

Analysis of the landscape of biologically-derived pharmaceuticals in Europe: Dominant production systems, molecule types on the rise and approval trends.

Integration of models and experimentation to optimise the production of potential biotherapeutics.

A systems biology approach to optimising hosts for industrial protein production.

Systematic methodology for the development of mathematical models for biological processes.

An optimized method for extraction and quantification of nucleotides and nucleotide sugars from mammalian cells.

Comparative analysis of amino acid metabolism and transport in CHO variants with different levels of productivity.

Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach.

Towards controlling the glycoform: a model framework linking extracellular metabolites to antibody glycosylation.

A framework for the systematic design of fed-batch strategies in mammalian cell culture.

Genetically-encoded biosensors for monitoring cellular stress in bioprocessing.

How does mild hypothermia affect monoclonal antibody glycosylation?

A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture.

Advances in the Development of Biotherapeutics.

Modelling of amorphous cellulose depolymerisation by cellulases, parametric studies and optimisation.

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation.

Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.

Whole-cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production.

Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.

Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation.

Host cell protein removal from biopharmaceutical preparations: Towards the implementation of quality by design.

Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture.

Model-based optimization of antibody galactosylation in CHO cell culture.

Low-cost and user-friendly biosensor to test the integrity of mRNA molecules suitable for field applications.

Harnessing the potential of artificial neural networks for predicting protein glycosylation.

High resolution biosensor to test the capping level and integrity of mRNAs.

The era of big data: Genome-scale modelling meets machine learning.

Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand.

Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform.

Glycoengineering Chinese hamster ovary cells: a short history.

Correction: Kis, Z. et al. Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand. 2021, , 3.

Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation.

Quality by design modelling to support rapid RNA vaccine production against emerging infectious diseases.

Rapid development and deployment of high-volume vaccines for pandemic response.

An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid.

Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics.

Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics.

Cell-free protein synthesis using Chinese hamster ovary cells.

Model Identifies Genetic Predisposition of Alzheimer's Disease as Key Decider in Cell Susceptibility to Stress.

Model-Based Planning and Delivery of Mass Vaccination Campaigns against Infectious Disease: Application to the COVID-19 Pandemic in the UK.

Pandemic-response adenoviral vector and RNA vaccine manufacturing.

Polymer Encapsulation of Bacterial Biosensors Enables Coculture with Mammalian Cells.

Population balance modelling captures host cell protein dynamics in CHO cell cultures.

Quality by Design for enabling RNA platform production processes.

Immunoglobulin G N-glycan Biomarkers for Autoimmune Diseases: Current State and a Glycoinformatics Perspective.