Ronald C. Conaway

MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression.

Roles of SCF and VHL ubiquitin ligases in regulation of cell growth.

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

Emerging roles of ubiquitin in transcription regulation.

A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase.

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.

The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription.

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.

Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.

The RNA polymerase II elongation complex.

TFIIS and GreB: two like-minded transcription elongation factors with sticky fingers.

Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.

Assays for investigating the mechanism of promoter escape by RNA polymerase II.

Preparation and assay of RNA polymerase II elongation factors elongin and ELL.

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

Identification of Elongin C and Skp1 sequences that determine Cullin selection.

Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.

In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development.

ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A.

The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.

The mammalian Mediator complex.

The mammalian Mediator complex and its role in transcriptional regulation.

ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.

In and out: histone variant exchange in chromatin.

Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.

Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.

Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors.

Identification and Characterization of a Schizosaccharomyces pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL.

RNA polymerase II: a "nobel" enzyme demystified.

YY1 functions with INO80 to activate transcription.

Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.

Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.

Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics.

New clues to actin function in chromatin regulation.

Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.

The INO80 chromatin remodeling complex in transcription, replication and repair.

Mediator comes out from the shadows.

Direct inhibition of RNA polymerase II transcription by RECQL5.

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.

Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4alpha and transcription factor IID.

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1.

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

Function and regulation of the Mediator complex.

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

Origins and activity of the Mediator complex.

The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.

Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes.

The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.

The Mediator complex and transcription elongation.

Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.

Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate.

Immunoaffinity purification of protein complexes from Mammalian cells.

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.

Transcriptional properties of mammalian elongin A and its role in stress response.

Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α.

Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.

Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex.

Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.