Chia-Yi Kuan

Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death.

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.

A critical role of neural-specific JNK3 for ischemic apoptosis.

Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism.

Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain.

Specific pathophysiological functions of JNK isoforms in the brain.

Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.

Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy.

Low doses of bromo- and iododeoxyuridine produce near-saturation labeling of adult proliferative populations in the dentate gyrus.

Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells.

Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth.

Saposin C: neuronal effect and CNS delivery by liposomes.

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.

The roles of autophagy in cerebral ischemia.

Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.

Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.

Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia.

Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.

Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice.

Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia.

Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.

Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway.

Developmental and post-injury cortical gliogenesis: a genetic fate-mapping study with Nestin-CreER mice.

Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.

Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke.

Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.

Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis.

Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury.

Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier.

Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone.

Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage.

Taming neonatal hypoxic-ischemic brain injury by intranasal delivery of plasminogen activator inhibitor-1.

Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.

Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke.

Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns.

Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation.

Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia.

Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection.

Towards reperfusion-centric preclinical stroke research: outside the box of "reperfusion injury".

Introduction of severe traumatic brain injury care protocol is associated with reduction in mortality for pediatric patients: a case study of Children's Healthcare of Atlanta's neurotrauma program.

Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury.

Early neutrophil infiltration is critical for inflammation-sensitized hypoxic-ischemic brain injury in newborns.

A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment.

Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke.

Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects.

Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury.