Chia-Yi Kuan

Department of Pediatrics, The Emory University School of Medicine

Affiliated withThe Emory University School of Medicine University of Virginia School of Medicine

Research Area

MedicineNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2015
Publication title	2021
Publication title	2025

Other Publications

Article	Year
Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death. Endocrinology\| PubMed ID: 12586782	2003
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The EMBO journal\| PubMed ID: 14517246	2003
A critical role of neural-specific JNK3 for ischemic apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657393	2003
Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism. The Journal of urology\| PubMed ID: 15371801	2004
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15564594	2004
Specific pathophysiological functions of JNK isoforms in the brain. The European journal of neuroscience\| PubMed ID: 15673436	2005
Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 15719422	2005
Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. Current drug targets. CNS and neurological disorders\| PubMed ID: 15723614	2005
Low doses of bromo- and iododeoxyuridine produce near-saturation labeling of adult proliferative populations in the dentate gyrus. The European journal of neuroscience\| PubMed ID: 15733099	2005
Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells. Development, growth & differentiation\| PubMed ID: 15839997	2005
Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16157885	2005
Saposin C: neuronal effect and CNS delivery by liposomes. Annals of the New York Academy of Sciences\| PubMed ID: 16179529	2005
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. The American journal of pathology\| PubMed ID: 16877357	2006
The roles of autophagy in cerebral ischemia. Autophagy\| PubMed ID: 17035724	2007
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17050694	2006
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17060633	2006
Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 17259645	2007
Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17409253	2007
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes & development\| PubMed ID: 17875667	2007
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy\| PubMed ID: 18188003	2008
Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Molecular vision\| PubMed ID: 18385792	2008
Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. The American journal of pathology\| PubMed ID: 18467699	2008
Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Developmental biology\| PubMed ID: 19007770	2009
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. Journal of neurochemistry\| PubMed ID: 19014392	2008
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway. The Journal of cell biology\| PubMed ID: 19114593	2008
Developmental and post-injury cortical gliogenesis: a genetic fate-mapping study with Nestin-CreER mice. Glia\| PubMed ID: 19115384	2009
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19587273	2009
Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21139628	2011
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21502507	2011
Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis. Journal of neuroscience methods\| PubMed ID: 21982741	2012
Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 22556277	2013
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury. Experimental neurology\| PubMed ID: 23353638	2013
Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23382178	2013
Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone. Genes & development\| PubMed ID: 23723414	2013
Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage. Science translational medicine\| PubMed ID: 23843451	2013
Taming neonatal hypoxic-ischemic brain injury by intranasal delivery of plasminogen activator inhibitor-1. Stroke; a journal of cerebral circulation\| PubMed ID: 23881953	2013
Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PloS one\| PubMed ID: 23904909	2013
Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke. PloS one\| PubMed ID: 24911517	2014
Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25471584	2014
Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation. CNS neuroscience & therapeutics\| PubMed ID: 25475942	2015
Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease. PloS one\| PubMed ID: 25506911	2014
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell\| PubMed ID: 25525875	2014
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. PloS one\| PubMed ID: 25531304	2014
Aryl hydrocarbon receptor mediates both proinflammatory and anti-inflammatory effects in lipopolysaccharide-activated microglia. Glia\| PubMed ID: 25690886	2015
Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection. Stroke; a journal of cerebral circulation\| PubMed ID: 26060244	2015
Towards reperfusion-centric preclinical stroke research: outside the box of "reperfusion injury". Neural regeneration research\| PubMed ID: 26170803	2015
Introduction of severe traumatic brain injury care protocol is associated with reduction in mortality for pediatric patients: a case study of Children's Healthcare of Atlanta's neurotrauma p... Journal of neurosurgery. Pediatrics\| PubMed ID: 29799350	2018
Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 30866741	2020
Early neutrophil infiltration is critical for inflammation-sensitized hypoxic-ischemic brain injury in newborns. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 31842667	2020
A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment. Blood advances\| PubMed ID: 32227212	2020
Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke. Science advances\| PubMed ID: 32923636	2020
Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 33127853	2020
Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury. Neurobiology of disease\| PubMed ID: 33248237	2021
Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI insight\| PubMed ID: 34324436	2021
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nature communications\| PubMed ID: 34489419	2021
Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism. Redox biology\| PubMed ID: 34826783	2021
Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. Theranostics\| PubMed ID: 34976198	2022
Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia. Neurobiology of disease\| PubMed ID: 35753626	2022
(Phospho)creatine: the reserve and merry-go-round of brain energetics. Neural regeneration research\| PubMed ID: 35900419	2023
Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature communications\| PubMed ID: 36433940	2022
Impaired post-stroke collateral circulation in sickle cell anemia mice. Frontiers in neurology\| PubMed ID: 37822524	2023
CCR2 monocytes replenish border-associated macrophages in the diseased mouse brain. Cell reports\| PubMed ID: 38625796	2024
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nature communications\| PubMed ID: 39843911	2025