Igor Koturbash

Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?

Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.

Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo.

Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo.

Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis.

Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.

DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models.

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.

In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen.

Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring.

Radiation-induced bystander effects in vivo are sex specific.

Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice.

Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism.

DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation.

Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner.

Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues.

Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression.

Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis.

Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model.

Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats.

Reversibility of pre-malignant estrogen-induced epigenetic changes.

Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.

Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment.

Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals.

Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.

Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.

Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.

Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.

Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants.

Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.

The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway.

Epigenetic alterations induced by ambient particulate matter in mouse macrophages.

Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung.

Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells.

The hypothalamic-pituitary-thyroid axis in infants and children: protection from radioiodines.

Age-dependent changes in DNA repair in radiation-exposed mice.

Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice.

Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats.

Short-term exposure to engineered nanomaterials affects cellular epigenome.

Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts.

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.

Response of transposable elements to environmental stressors.

In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter.

The Fine LINE: Methylation Drawing the Cancer Landscape.

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment.

Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung.

In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles.

Space radiation and cardiovascular disease risk.

A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation.

Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.

Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: A case study of toxicological implications from nanomaterials released during consumer use.

The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage.

Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.

Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner.

Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations.

Effects of ionizing radiation on the heart.