Kinya Hotta

Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism.

Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole.

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.

Precursor-directed biosynthesis of epothilone in Escherichia coli.

Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles.

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

Biosynthesis of the 3,4-dihydroxybenzoate moieties of petrobactin by Bacillus anthracis.

The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.

Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli.

Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli.

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.

Siderophore-mediated iron acquisition in Bacillus anthracis and related strains.

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis.

Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics.

Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce a novel polyketide.

Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis.

Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.

Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products.

Echinomycin biosynthesis.

Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.

Engineering the polyproline II propensity of a class II major histocompatibility complex ligand peptide.

Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk.

Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis.

Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis.

Biophysical properties of intrinsically disordered p130Cas substrate domain--implication in mechanosensing.

Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity.

Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.

Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.

Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.

Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation.

Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.