Vasso Episkopou

SOX2 functions in adult neural stem cells.

Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

Sox2 and Pou2f1 interact to control lens and olfactory placode development.

Pax6 is misexpressed in Sox1 null lens fiber cells.

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

Dual function of Sox1 in telencephalic progenitor cells.

Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors.

High yield expression and NMR characterization of Arkadia E3 ubiquitin ligase RING-H2 finger domain.

TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis.

Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.

The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development.

Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.

Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.