Lucilia Saraiva

New insights into cancer-related proteins provided by the yeast model.

New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems.

Endocytosis inhibition during H2O2-induced apoptosis in yeast.

Interference of aging media on the assessment of yeast chronological life span by propidium iodide staining.

Contribution of yeast and plant research for improving human health.

Contribution of yeast models to neurodegeneration research.

SNaPaer: a practical single nucleotide polymorphism multiplex assay for genotyping of Pseudomonas aeruginosa.

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.

LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model.

Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis.

Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.

A yeast model of the Parkinson's disease-associated protein Parkin.

A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.

Chronological aging in conidia of pathogenic Aspergillus: Comparison between species.

Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.

p53 family interactions and yeast: together in anticancer therapy.

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

p53 and glucose metabolism: an orchestra to be directed in cancer therapy.

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.

Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity.

Improving anticancer activity towards colon cancer cells with a new p53-activating agent.

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma.

Comparison Study of Different Extracts of , and the Rare (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities.

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents.