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LAQV/REQUIMTE,
Laboratory of Microbiology,
Faculty of Pharmacy,
LAQV/REQUIMTE, Laboratory of Microbiology, Faculty of Pharmacy
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New insights into cancer-related proteins provided by the yeast model.
The FEBS journal Mar, 2012 | Pubmed ID: 22239976
New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems.
Current pharmaceutical design , 2012 | Pubmed ID: 22650181
Endocytosis inhibition during H2O2-induced apoptosis in yeast.
FEMS yeast research Nov, 2012 | Pubmed ID: 22741558
Interference of aging media on the assessment of yeast chronological life span by propidium iodide staining.
Folia microbiologica Jan, 2013 | Pubmed ID: 22828896
Contribution of yeast and plant research for improving human health.
Journal of biomedicine & biotechnology , 2012 | Pubmed ID: 22851885
Contribution of yeast models to neurodegeneration research.
Journal of biomedicine & biotechnology , 2012 | Pubmed ID: 22910375
SNaPaer: a practical single nucleotide polymorphism multiplex assay for genotyping of Pseudomonas aeruginosa.
PloS one , 2013 | Pubmed ID: 23776608
Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Apr, 2014 | Pubmed ID: 24398107
LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model.
Biochimica et biophysica acta Jun, 2014 | Pubmed ID: 24576675
Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis.
Journal of neuroinflammation Sep, 2014 | Pubmed ID: 25178395
Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.
Experimental cell research Jan, 2015 | Pubmed ID: 25265062
Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2015 | Pubmed ID: 25312347
A yeast model of the Parkinson's disease-associated protein Parkin.
Experimental cell research Apr, 2015 | Pubmed ID: 25728007
A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.
Pharmacological research May-Jun, 2015 | Pubmed ID: 25814188
Chronological aging in conidia of pathogenic Aspergillus: Comparison between species.
Journal of microbiological methods Nov, 2015 | Pubmed ID: 26341609
Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.
Life sciences Dec, 2015 | Pubmed ID: 26475964
p53 family interactions and yeast: together in anticancer therapy.
Drug discovery today Apr, 2016 | Pubmed ID: 26891980
Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.
Medicinal research reviews 09, 2016 | Pubmed ID: 27302609
Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.
Cell death & disease 01, 2018 | Pubmed ID: 29348560
p53 and glucose metabolism: an orchestra to be directed in cancer therapy.
Pharmacological research 05, 2018 | Pubmed ID: 29580896
The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.
International journal of molecular sciences Apr, 2018 | Pubmed ID: 29652801
Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity.
European journal of medicinal chemistry Aug, 2018 | Pubmed ID: 30041135
Improving anticancer activity towards colon cancer cells with a new p53-activating agent.
British journal of pharmacology 10, 2018 | Pubmed ID: 30076608
New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.
Molecules (Basel, Switzerland) Dec, 2018 | Pubmed ID: 30602686
New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma.
Cancer letters Apr, 2019 | Pubmed ID: 30664963
Comparison Study of Different Extracts of , and the Rare (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities.
Biomolecules May, 2019 | Pubmed ID: 31072074
Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents.
Molecules (Basel, Switzerland) May, 2019 | Pubmed ID: 31121972
University of Porto
Paola Monti1,
Bartolomeo Bosco2,
Sara Gomes3,
Lucilia Saraiva*,3,
Gilberto Fronza*,1,
Alberto Inga*,2
1Mutagenesis and Cancer Prevention Unit, Ospedale Policlinico San Martino,
2Department CIBIO, University of Trento,
3LAQV/REQUIMTE, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto
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