Edwin K. Jackson

Adenosine-mediated inhibition of the cytotoxic activity and cytokine production by activated natural killer cells.

Sex hormones and hypertension.

A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells.

Long-term caffeine consumption exacerbates renal failure in obese, diabetic, ZSF1 (fa-fa(cp)) rats.

Catecholamines block 2-hydroxyestradiol-induced antimitogenesis in mesangial cells.

Expression of adenosine receptors in the preglomerular microcirculation.

Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology.

2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy.

alpha 2-Adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats.

Role of EGFR transactivation in angiotensin II signaling to extracellular regulated kinase in preglomerular smooth muscle cells.

Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats.

Oviduct cells express the cyclic AMP-adenosine pathway.

Methylation of 2-hydroxyestradiol in isolated organs.

Rat models of the metabolic syndrome.

Renal extraction of angiotensin II.

Adenosine biosynthesis in the collecting duct.

Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice.

AT2 receptors attenuate AT1 receptor-induced phospholipase D activation in vascular smooth muscle cells.

2-hydroxyestradiol is a prodrug of 2-methoxyestradiol.

The extracellular cyclic AMP-adenosine pathway in renal physiology.

Vascular endothelial growth factor is increased in cerebrospinal fluid after traumatic brain injury in infants and children.

Modulation of cyclic AMP production by signal transduction pathways in preglomerular microvessels and microvascular smooth muscle cells.

A gas chromatography/mass spectrometry assay to measure estradiol, catecholestradiols, and methoxyestradiols in plasma.

Increased expression of the sodium transporter BSC-1 in spontaneously hypertensive rats.

Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers.

Hormone replacement therapy and cardiovascular disease: what went wrong and where do we go from here?

Intraperitoneal administration of adenosine inhibits formation of abdominal adhesions.

Enhanced activation of RhoA by angiotensin II in SHR preglomerular microvascular smooth muscle cells.

Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen.

Mechanism of the vascular angiotensin II/alpha2-adrenoceptor interaction.

Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging.

Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition.

Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A(2B) receptors.

Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury.

Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats.

Gs protein-coupled adenosine receptor signaling and lytic function of activated NK cells.

Pancreatic polypeptide-fold peptide receptors and angiotensin II-induced renal vasoconstriction.

cAMP-adenosine pathway in the proximal tubule.

Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats.

2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension.

A2A adenosine receptor protects tumors from antitumor T cells.

Conversion of tibolone to 7alpha-methyl-ethinyl estradiol using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry: interpretation and clinical implications.

The extracellular cAMP-adenosine pathway significantly contributes to the in vivo production of adenosine.

2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats.

PPAR alpha agonists improve renal preservation in kidneys subjected to chronic in vitro perfusion: interaction with mannitol.

Characterization of renal ecto-phosphodiesterase.

Phospholipase C and Src modulate angiotensin II-induced cyclic AMP production in preglomerular microvascular smooth-muscle cells from spontaneously hypertensive rats.

The pancreatohepatorenal cAMP-adenosine mechanism.

Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I).

Norepinephrine, via beta-adrenoceptors, regulates bumetanide-sensitive cotransporter type 1 expression in thick ascending limb cells.

Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling.

Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs.

Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.

Inhibition of renal dipeptidyl peptidase IV enhances peptide YY1-36-induced potentiation of angiotensin II-mediated renal vasoconstriction in spontaneously hypertensive rats.

Cellular distribution of the renal bumetanide-sensitive Na-K-2Cl cotransporter BSC-1 in the inner stripe of the outer medulla during the development of hypertension in the spontaneously hypertensive rat.

Early renal injury induced by caffeine consumption in obese, diabetic ZSF1 rats.

Importance of tissue perfusion in ST segment elevation myocardial infarction patients undergoing reperfusion strategies: role of adenosine.

Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia.

Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure.

Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2.

Regulation of renal ectophosphodiesterase by protein kinase C and sodium diet.

Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.

Assessment of nerve stimulation-induced release of purines from mouse kidneys by tandem mass spectrometry.

2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling.

Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension.

Identification and quantification of 2',3'-cAMP release by the kidney.

Treating acute "no-reflow" with intracoronary adenosine in 4 patients during percutaneous coronary intervention.

Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphate.

Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension.

Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats.

2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats.

Multidrug resistance protein 4 mediates cAMP efflux from rat preglomerular vascular smooth muscle cells.

Potential vascular actions of 2-methoxyestradiol.

Effects of estradiol metabolites on cAMP production and degradation.

Extracellular 2',3'-cAMP is a source of adenosine.

Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer.

Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells.

Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice.

Extracellular 3',5'-cAMP-adenosine pathway inhibits glomerular mesangial cell growth.

Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome.

Extracellular 2,3-cyclic adenosine monophosphate is a potent inhibitor of preglomerular vascular smooth muscle cell and mesangial cell growth [corrected].

Resveratrol, a red wine constituent, blocks the antimitogenic effects of estradiol on human female coronary artery smooth muscle cells.

Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells.

Estradiol stimulates capillary formation by human endothelial progenitor cells: role of estrogen receptor-{alpha}/{beta}, heme oxygenase 1, and tyrosine kinase.

Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling.

Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection.

Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes.

Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats.

2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors.

Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury.

Role of sphingosine-1-phosphate in the renal medulla.

2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors.

Extracellular cAMP-adenosine pathways in the mouse kidney.

Expression of the 2',3'-cAMP-adenosine pathway in astrocytes and microglia.

Receptor for activated protein kinase C1 regulates cell proliferation by modulating calcium signaling.

The 2',3'-cAMP-adenosine pathway.

Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.

Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1 receptor-mediated coincident signaling.

Hypertension, tachycardia, and reversible cardiomyopathy temporally associated with milnacipran use.

Increased adenosine concentration in bronchoalveolar lavage fluid of horses with lower airway inflammation.

The brain in vivo expresses the 2',3'-cAMP-adenosine pathway.

Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.

Extracellular 2',3'-cAMP and 3',5'-cAMP stimulate proliferation of preglomerular vascular endothelial cells and renal epithelial cells.

Dipeptidyl peptidase IV regulates proliferation of preglomerular vascular smooth muscle and mesangial cells.

Role of A1 receptors in renal sympathetic neurotransmission in the mouse kidney.

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.

Extracellular 2',3'-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells.

Extracellular guanosine regulates extracellular adenosine levels.

Role of RACK1 in the differential proliferative effects of neuropeptide Y(1-36) and peptide YY(1-36) in SHR vs. WKY preglomerular vascular smooth muscle cells.

Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats.

Adenosine production by human B cells and B cell-mediated suppression of activated T cells.

In vivo cardiovascular pharmacology of 2',3'-cAMP, 2'-AMP, and 3'-AMP in the rat.

CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice.

Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease.

Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway.

Regulation of Cell Proliferation by the Guanosine-Adenosine Mechanism: Role of Adenosine Receptors.

The β-blocker Nebivolol Is a GRK/β-arrestin biased agonist.

CD4⁺CD73⁺ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression.

Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes.

Role of CD73 in Renal Sympathetic Neurotransmission in the Mouse Kidney.

A novel adenosine precursor 2',3'-cyclic adenosine monophosphate inhibits formation of post-surgical adhesions.

Hemorrhagic shock shifts the serum cytokine profile from pro- to anti-inflammatory after experimental traumatic brain injury in mice.

Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.

Guanosine regulates adenosine levels in the kidney.

Interactive roles of CD73 and tissue nonspecific alkaline phosphatase in the renal vascular metabolism of 5'-AMP.

The guanosine-adenosine interaction exists in vivo.

Angiotensin II type 2 receptor regulates ROMK-like K⁺ channel activity in the renal cortical collecting duct during high dietary K⁺ adaptation.

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.

Prevention of skin carcinogenesis by the β-blocker carvedilol.

Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent.

2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors.

Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema.

The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.

Emerging therapies in traumatic brain injury.

Immunological mechanisms of the antitumor effects of supplemental oxygenation.

Detection of PHLPP1α/β in human and mouse brain by different anti-PHLPP1 antibodies.

Schwann Cells Metabolize Extracellular 2',3'-cAMP to 2'-AMP.

Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.

Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues.

Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons.

NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4.

Adenosine Attenuates Human Coronary Artery Smooth Muscle Cell Proliferation by Inhibiting Multiple Signaling Pathways That Converge on Cyclin D.

2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells.

Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion.

Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.

Discovery and Roles of 2',3'-cAMP in Biological Systems.

2-Methoxyestradiol, an endogenous 17β-estradiol metabolite, inhibits microglial proliferation and activation via an estrogen receptor-independent mechanism.

Purines: forgotten mediators in traumatic brain injury.

Adenosine metabolism of human mesenchymal stromal cells isolated from patients with head and neck squamous cell carcinoma.

Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension.

8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity.

The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.

Context-dependent effects of dipeptidyl peptidase 4 inhibitors.

RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells.

Alkaline Phosphatase Inhibitors Attenuate Renovascular Responses to Norepinephrine.

Editorial for "Hypertension's 3 Dilemmas & 3 Solutions: Pharmacology of the Kidney in Hypertension".

Adenosine production by brain cells.

Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer.

Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway.

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms.

8-Aminoguanosine Exerts Diuretic, Natriuretic, and Glucosuric Activity via Conversion to 8-Aminoguanine, Yet Has Direct Antikaliuretic Effects.

Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia.

SDF-1α (Stromal Cell-Derived Factor 1α) Induces Cardiac Fibroblasts, Renal Microvascular Smooth Muscle Cells, and Glomerular Mesangial Cells to Proliferate, Cause Hypertrophy, and Produce Collagen.

BrainPhys® increases neurofilament levels in CNS cultures, and facilitates investigation of axonal damage after a mechanical stretch-injury in vitro.

The influence of chemotherapy on adenosine-producing B cells in patients with head and neck squamous cell carcinoma.

Captopril Attenuates Cardiovascular and Renal Disease in a Rat Model of Heart Failure With Preserved Ejection Fraction.

Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice.

Adenosine Receptors Influence Hypertension in Dahl Salt-Sensitive Rats: Dependence on Receptor Subtype, Salt Diet, and Sex.

Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Aging increases the expression of vasopressin receptors in both the kidney and urinary bladder.

Extracellular Ubiquitin(1-76) and Ubiquitin(1-74) Regulate Cardiac Fibroblast Proliferation.

Oxidative stress induces release of 2'-AMP from microglia.

Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision.

8-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1.

2',3'-cGMP exists in vivo and comprises a 2',3'-cGMP-guanosine pathway.

2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury.

Mechanism of 17β-estradiol stimulated integration of human mesenchymal stem cells in heart tissue.

A Randomized, Placebo-Controlled, Pilot Clinical Trial of Dipyridamole to Decrease Human Immunodeficiency Virus-Associated Chronic Inflammation.

Adenosine, Via A Receptors, Inhibits Human (P-SMC) Progenitor Smooth Muscle Cell Growth.

Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension.

DPP4 Inhibition, NPY, PYY, SDF-1, and a Hypertensive Genetic Background Conspire to Augment Cell Proliferation and Collagen Production: Effects That Are Abolished by Low Concentrations of 2-Methoxyestradiol.

Adenosine-producing regulatory B cells in head and neck cancer.

Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness.

Intercalated cell BKα subunit is required for flow-induced K+ secretion.

Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2'3'-cAMP.

Identification of Novel Targets of RBM5 in the Healthy and Injured Brain.

Characterization of the N-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism.

Tumor-derived exosomes promote angiogenesis via adenosine A receptor signaling.

-Adrenoceptors: Challenges and Opportunities-Enlightenment from the Kidney.

Adenosine receptors regulate exosome production.

Role of exosome-associated adenosine in promoting angiogenesis.

Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma.

Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer.

Author Correction: Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2',3'-cAMP.

Alkaline Phosphatase Activity Is a Key Determinant of Vascular Responsiveness to Norepinephrine.

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions.

A uro-protective agent with restorative actions on urethral and striated muscle morphology.

Brief Report: Dipyridamole Decreases Gut Mucosal Regulatory T-Cell Frequencies Among People With HIV on Antiretroviral Therapy.

Novel Guidewire Design and Coating for Continuous Delivery of Adenosine During Interventional Procedures.

Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats.

Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT receptor-forkhead box subclass O transcription factor signalling axis.

Modulation of Cyclic AMP Levels in Fallopian Tube Cells by Natural and Environmental Estrogens.