Chuan-ju Liu

The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.

Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B.

Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular trafficking.

A silencer element in the cartilage oligomeric matrix protein gene regulates chondrocyte-specific expression.

Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.

The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.

Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty.

p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.

p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.

ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.

Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation.

Protein-protein interactions and membrane localization of the human organic solute transporter.

The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity.

Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators.

IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells.

RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer.

p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins.

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.

p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation.

The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.

ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.

miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1.

MicroRNAs in skeletogenesis.

ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.

Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study.

Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.

Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth.

Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue.

GEP, a local growth factor, is critical for odontogenesis and amelogenesis.

The role of ADAMTSs in arthritis.

Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Progranulin: a promising therapeutic target for rheumatoid arthritis.

Progranulin: a growth factor, a novel TNFR ligand and a drug target.

GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.

Prevention of atrophic nonunion by the systemic administration of parathyroid hormone (PTH 1-34) in an experimental animal model.

Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling.

ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis.

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains.

Progranulin inhibition of TNFα

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.

ADAMTS-18: a metalloproteinase with multiple functions.

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.

Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.

Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice.

Progranulin knockout accelerates intervertebral disc degeneration in aging mice.

Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?: Comment on Olson et al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture".

Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling.

Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.

Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling.

Association Between Progranulin and Gaucher Disease.

Progranulin: A key player in autoimmune diseases.

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis.

Multifunctional molecule ERp57: From cancer to neurodegenerative diseases.

Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes.

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.

Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease.

p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.

Molecular regulations and therapeutic targets of Gaucher disease.

Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.

Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis.

Targeting tumor necrosis factor receptors in ankylosing spondylitis.

Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease.

Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models.

Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review.

Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases.

Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.

Progranulin promotes diabetic fracture healing in mice with type 1 diabetes.