Department of Orthopaedic Surgery
Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS.
The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.
Molecular and cellular biology May, 2002 | Pubmed ID: 11940648
Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B.
The Journal of biological chemistry Jan, 2003 | Pubmed ID: 12401812
Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na+-dependent bile acid transporter: protein-protein interaction and intracellular trafficking.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14752118
A silencer element in the cartilage oligomeric matrix protein gene regulates chondrocyte-specific expression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jul, 2004 | Pubmed ID: 15183430
Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15337766
The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.
The Journal of biological chemistry Jan, 2005 | Pubmed ID: 15557274
Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty.
The Journal of bone and joint surgery. American volume Sep, 2005 | Pubmed ID: 16140805
p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.
The Journal of biological chemistry May, 2006 | Pubmed ID: 16556595
p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.
The Journal of biological chemistry May, 2006 | Pubmed ID: 16556596
ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2006 | Pubmed ID: 16585064
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16611630
Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation.
The Journal of biological chemistry Apr, 2007 | Pubmed ID: 17307734
Protein-protein interactions and membrane localization of the human organic solute transporter.
American journal of physiology. Gastrointestinal and liver physiology Jun, 2007 | Pubmed ID: 17332473
The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity.
The Journal of biological chemistry Jun, 2007 | Pubmed ID: 17439944
Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators.
Frontiers in bioscience : a journal and virtual library , 2007 | Pubmed ID: 17485346
IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells.
Frontiers in bioscience : a journal and virtual library , 2007 | Pubmed ID: 17569615
RbAp48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer.
The Journal of biological chemistry Sep, 2007 | Pubmed ID: 17616526
p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins.
Molecular biology of the cell May, 2008 | Pubmed ID: 18287524
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.
Osteoarthritis and cartilage Nov, 2008 | Pubmed ID: 18485748
p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation.
Cytokine & growth factor reviews Oct-Dec, 2008 | Pubmed ID: 19027346
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
Nature clinical practice. Rheumatology Jan, 2009 | Pubmed ID: 19098927
ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.
Circulation research Mar, 2009 | Pubmed ID: 19168437
miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1.
The Journal of biological chemistry Apr, 2009 | Pubmed ID: 19251704
MicroRNAs in skeletogenesis.
Frontiers in bioscience : a journal and virtual library , 2009 | Pubmed ID: 19273234
ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.
Molecular and cellular biology Aug, 2009 | Pubmed ID: 19487464
Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study.
Clinical orthopaedics and related research Dec, 2009 | Pubmed ID: 19597895
Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.
Circulation research Feb, 2010 | Pubmed ID: 20019333
Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2010 | Pubmed ID: 20124436
Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth.
Matrix biology : journal of the International Society for Matrix Biology May, 2010 | Pubmed ID: 20138147
Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue.
Journal of orthopaedic trauma Sep, 2010 | Pubmed ID: 20736794
GEP, a local growth factor, is critical for odontogenesis and amelogenesis.
International journal of biological sciences , 2010 | Pubmed ID: 21152114
The role of ADAMTSs in arthritis.
Protein & cell Jan, 2010 | Pubmed ID: 21203996
Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
Circulation research Apr, 2011 | Pubmed ID: 21350216
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.
Science (New York, N.Y.) Apr, 2011 | Pubmed ID: 21393509
Progranulin: a promising therapeutic target for rheumatoid arthritis.
FEBS letters Dec, 2011 | Pubmed ID: 21550343
Progranulin: a growth factor, a novel TNFR ligand and a drug target.
Pharmacology & therapeutics Jan, 2012 | Pubmed ID: 22008260
GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.
Cellular and molecular life sciences : CMLS Dec, 2011 | Pubmed ID: 22179841
Prevention of atrophic nonunion by the systemic administration of parathyroid hormone (PTH 1-34) in an experimental animal model.
Journal of orthopaedic trauma Dec, 2012 | Pubmed ID: 22932751
Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.
FEBS letters Jun, 2013 | Pubmed ID: 23669357
The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling.
Biomaterials Sep, 2013 | Pubmed ID: 23746860
ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis.
Annals of the rheumatic diseases Dec, 2013 | Pubmed ID: 23928557
Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains.
FEBS letters Nov, 2013 | Pubmed ID: 24070898
Progranulin inhibition of TNFα
Immunology and cell biology Feb, 2014 | Pubmed ID: 24518982
Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.
Frontiers in bioscience (Landmark edition) Jun, 2014 | Pubmed ID: 24896343
ADAMTS-18: a metalloproteinase with multiple functions.
Frontiers in bioscience (Landmark edition) Jun, 2014 | Pubmed ID: 24896365
Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.
Annals of the rheumatic diseases Dec, 2015 | Pubmed ID: 25169730
PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.
Scientific reports Nov, 2014 | Pubmed ID: 25387791
Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.
PloS one , 2014 | Pubmed ID: 25393765
Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice.
Molecular and cellular biochemistry Jun, 2015 | Pubmed ID: 25742929
Progranulin knockout accelerates intervertebral disc degeneration in aging mice.
Scientific reports Mar, 2015 | Pubmed ID: 25777988
Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?: Comment on Olson et al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture".
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jan, 2016 | Pubmed ID: 26519939
Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling.
Scientific reports Feb, 2016 | Pubmed ID: 26864916
Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 08, 2016 | Pubmed ID: 27075243
Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling.
Arthritis & rheumatology (Hoboken, N.J.) 12, 2016 | Pubmed ID: 27428882
Association Between Progranulin and Gaucher Disease.
EBioMedicine Sep, 2016 | Pubmed ID: 27515686
Progranulin: A key player in autoimmune diseases.
Cytokine 01, 2018 | Pubmed ID: 27527809
Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
EBioMedicine Nov, 2016 | Pubmed ID: 27789271
Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 04, 2017 | Pubmed ID: 28011648
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases.
Pharmacology & therapeutics 01, 2018 | Pubmed ID: 28723413
Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes.
Genes & diseases Sep, 2017 | Pubmed ID: 28944282
Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.
Arthritis research & therapy Dec, 2017 | Pubmed ID: 29258611
Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease.
EBioMedicine Feb, 2018 | Pubmed ID: 29396296
p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.
EBioMedicine Mar, 2018 | Pubmed ID: 29472103
Molecular regulations and therapeutic targets of Gaucher disease.
Cytokine & growth factor reviews 06, 2018 | Pubmed ID: 29699937
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
Arthritis & rheumatology (Hoboken, N.J.) 11, 2018 | Pubmed ID: 29750395
Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29956284
Targeting tumor necrosis factor receptors in ankylosing spondylitis.
Annals of the New York Academy of Sciences Apr, 2019 | Pubmed ID: 30008173
Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease.
Journal of molecular medicine (Berlin, Germany) Dec, 2018 | Pubmed ID: 30341570
Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models.
EBioMedicine 12, 2018 | Pubmed ID: 30522930
Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review.
JBJS reviews Jan, 2019 | Pubmed ID: 30694878
Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases.
Cytokine & growth factor reviews 02, 2019 | Pubmed ID: 30733059
Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.
Annals of the rheumatic diseases Jul, 2019 | Pubmed ID: 31302596
Progranulin promotes diabetic fracture healing in mice with type 1 diabetes.
Annals of the New York Academy of Sciences Aug, 2019 | Pubmed ID: 31423598
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