Jeremy C. Simpson

Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway.

Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth.

Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line.

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.

Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images.

High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells.

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.

A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients.

Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A.

Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells.

Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells.

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc).

A real-time impedance based method to assess Rhodococcus equi virulence.

Human diseases associated with form and function of the Golgi complex.

Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles.

High-content screening and analysis of the Golgi complex.

RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells.

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.

Actin in action: imaging approaches to study cytoskeleton structure and function.

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport.

Trajectory-based co-localization measures for nanoparticle-cell interaction studies.

Biocompatibility of ferroelectric lithium niobate and the influence of polarization charge on osteoblast proliferation and function.

Hydroxyapatite and fluorapatite coatings on dental screws: effects of blast coating process and biological response.

A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways.

High-content analysis for drug delivery and nanoparticle applications.

A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking.

High-content analysis of Rab protein function at the ER-Golgi interface.

Implementation of the Rank-Weighted Co-localization (RWC) algorithm in multiple image analysis platforms for quantitative analysis of microscopy images.

Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time.

A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells.

Genome-Wide siRNA Screening Using Forward Transfection: Identification of Modulators of Membrane Trafficking in Mammalian Cells.

Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.

Systematic functional analysis of the Ras GTPase family unveils a conserved network required for anterograde protein trafficking.

Functional characterisation of the YIPF protein family in mammalian cells.

Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans.

Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.

Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches.

Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells.

Rapid Growth Cone Uptake and Dynein-Mediated Axonal Retrograde Transport of Negatively Charged Nanoparticles in Neurons Is Dependent on Size and Cell Type.

Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome.

A High-Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids.

Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b.

The Challenges and Possibilities of Extracellular Vesicles as Therapeutic Vehicles.

Rab35 controls cilium length, function and membrane composition.

NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases.

Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni.

Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells.

SCLpred-EMS: subcellular localization prediction of endomembrane system and secretory pathway proteins by Deep N-to-1 Convolutional Neural Networks.

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes.

Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells.

RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells.

Emerging roles for Rho GTPases operating at the Golgi complex.

Antimicrobial effects of airborne acoustic ultrasound and plasma activated water from cold and thermal plasma systems on biofilms.

A novel high-content screening approach for the elucidation of C. jejuni biofilm composition and integrity.

Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms.

A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells.

Multiparametric nanoparticle-induced toxicity readouts with single cell resolution in HepG2 multicellular tumour spheroids.

2D-GolgiTrack-a semi-automated tracking system to quantify morphological changes and dynamics of the Golgi apparatus and Golgi-derived membrane tubules.

Cell3: A new vision for study of the endomembrane system in mammalian cells.

Cell3: a new vision for study of the endomembrane system in mammalian cells.