Daniel G. Anderson

Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery.

Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery.

Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery.

Degradable poly(amino alcohol esters) as potential DNA vectors with low cytotoxicity.

pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles.

Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.

Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines.

pH-triggered microparticles for peptide vaccination.

Materials science. Smart biomaterials.

A polymer library approach to suicide gene therapy for cancer.

Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters).

Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction.

Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization.

Direct patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps.

Biodegradable polymeric vectors for gene delivery to human endothelial cells.

Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery.

Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells.

Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s.

Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors.

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway.

Gene delivery properties of end-modified poly(beta-amino ester)s.

TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettability.

Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors.

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery.

Nanoparticle delivery of suicide DNA for epithelial ovarian cancer therapy.

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.

Nanoparticles for gene transfer to human embryonic stem cell colonies.

Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation.

Assessing siRNA pharmacodynamics in a luciferase-expressing mouse.

Cell-compatible, multicomponent protein arrays with subcellular feature resolution.

Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Poly(beta-amino esters): procedures for synthesis and gene delivery.

Knocking down barriers: advances in siRNA delivery.

Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis.

Development of lipidoid-siRNA formulations for systemic delivery to the liver.

Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery.

A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery.

Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery.

Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs.

High-throughput membrane surface modification to control NOM fouling.

Drug delivery-mediated control of RNA immunostimulation.

Minicells overcome tumor drug-resistance.

High throughput optimization of stem cell microenvironments.

Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice.

Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules.

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles.

Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.

High throughput methods applied in biomaterial development and discovery.

Tissue-specific gene delivery via nanoparticle coating.

Lipid-like materials for low-dose, in vivo gene silencing.

Nanoparticulate cellular patches for cell-mediated tumoritropic delivery.

Electrostatic surface modifications to improve gene delivery.

Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.

Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D.

Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery.

Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells.

CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy.

A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells.

Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays.

An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate.

High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays.

DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and protein nanoparticles.

Real-time in vivo detection of biomaterial-induced reactive oxygen species.

A novel family of biodegradable poly(ester amide) elastomers.

Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response.

Chondrogenic priming adipose-mesenchymal stem cells for cartilage tissue regeneration.

Development of cationic polymer coatings to regulate foreign-body responses.

Degradable polyelectrolyte multilayers that promote the release of siRNA.

Five years of siRNA delivery: spotlight on gold nanoparticles.

Poly(β-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies.

Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.

Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture.

Nanoparticles targeting the infarcted heart.

Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain.

The influence of scaffold elasticity on germ layer specification of human embryonic stem cells.

Therapeutic siRNA silencing in inflammatory monocytes in mice.

Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.

Combinatorial library of lipidoids for in vitro DNA delivery.

Alkane-modified short polyethyleneimine for siRNA delivery.

Treating metastatic cancer with nanotechnology.

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles.

Origins of tumor-associated macrophages and neutrophils.