Joseph P. Noel

Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences.

Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.

Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family.

Role of hydrogen bonds in the reaction mechanism of chalcone isomerase.

Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity.

Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase.

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.

The chalcone synthase superfamily of type III polyketide synthases.

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region.

Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family.

Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.

Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens.

Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids.

An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases.

Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes.

A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases.

Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase.

Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase.

Structure-function relationships in plant phenylpropanoid biosynthesis.

Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding.

Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function.

Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products.

Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis.

An Arabidopsis thaliana methyltransferase capable of methylating farnesoic acid.

Stereochemistry and deuterium isotope effects associated with the cyclization-rearrangements catalyzed by tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases, and the chimeric CH4 hybrid cyclase.

Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase.

Biosynthesis of plant volatiles: nature's diversity and ingenuity.

Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway.

Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases.

Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester.

Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases.

Structure-function-folding relationship in a WW domain.

Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.

Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.

Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula.

Metabolic engineering of sesquiterpene metabolism in yeast.

Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining.

Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.

Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses.

Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1.

Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.

Methylation of gibberellins by Arabidopsis GAMT1 and GAMT2.

Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization.

Structural basis for high-affinity peptide inhibition of human Pin1.

A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates.

Genetically encoding unnatural amino acids for cellular and neuronal studies.

Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates.

Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.

Structure and reaction mechanism of basil eugenol synthase.

Digging for answers, smelling a hint of success and tasting triumph.

Discovery and characterization of a marine bacterial SAM-dependent chlorinase.

Structural, biochemical, and phylogenetic analyses suggest that indole-3-acetic acid methyltransferase is an evolutionarily ancient member of the SABATH family.

The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages.

Evolving biosynthetic tangos negotiate mechanistic landscapes.

Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx.

Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.

Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities.

S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases.

Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain.

The lack of floral synthesis and emission of isoeugenol in Petunia axillaris subsp. parodii is due to a mutation in the isoeugenol synthase gene.

Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes.

Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates.

Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates.

Enzymatic functions of wild tomato methylketone synthases 1 and 2.

Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne).

Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference.

Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids.

Structural basis of steroid hormone perception by the receptor kinase BRI1.

Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons.

Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato.

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

The rise of chemodiversity in plants.

Architectures, mechanisms and molecular evolution of natural product methyltransferases.

Structure-function analyses of plant type III polyketide synthases.

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase.

Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.

Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future.

Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis.

Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants.

Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings.

Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.

Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Discovery of a metabolic alternative to the classical mevalonate pathway.

Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells.

Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus.

Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis.

Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants.

Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases.

Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light.

Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products.

Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair.

Local auxin metabolism regulates environment-induced hypocotyl elongation.

Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.

Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity.

Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom.

Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase.

Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246].

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.

A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis.

Molecular architectures of benzoic acid-specific type III polyketide synthases.

A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae.

Evolution of chalcone isomerase from a noncatalytic ancestor.

Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor.

Contribution of isopentenyl phosphate to plant terpenoid metabolism.

Strigolactone perception and deactivation by a hydrolase receptor DWARF14.

Dissecting modular synthases through inhibition: A complementary chemical and genetic approach.

Gating mechanism of elongating β-ketoacyl-ACP synthases.

Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway.

Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an -prenyltransferase.

Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis.

Interfacial plasticity facilitates high reaction rate of FAS malonyl-CoA:ACP transacylase, FabD.

Plant-based CO drawdown and storage as SiC.