Dmitry Lyumkis

Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy.

Single-particle cryoEM analysis at near-atomic resolution from several thousand asymmetric subunits.

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

Structural Basis for the Activation of IKK1/α.

Modular Assembly of the Bacterial Large Ribosomal Subunit.

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.

Addressing preferred specimen orientation in single-particle cryo-EM through tilting.

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.

Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant.

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.

Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification.

Challenges and opportunities in cryo-EM single-particle analysis.

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.

Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease.

Non-uniformity of projection distributions attenuates resolution in Cryo-EM.

SrmB Rescues Trapped Ribosome Assembly Intermediates.

Structural basis for strand-transfer inhibitor binding to HIV intasomes.

HIV-1 Integrase Inhibitors That Are Active against Drug-Resistant Integrase Mutants.

Structural Biology of HIV Integrase Strand Transfer Inhibitors.

Tools for visualizing and analyzing Fourier space sampling in Cryo-EM.

Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.

Evaluating Local and Directional Resolution of Cryo-EM Density Maps.

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs.

HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.

Retroviral integrase: Structure, mechanism, and inhibition.

Quantitative mining of compositional heterogeneity in cryo-EM datasets of ribosome assembly intermediates.

Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity.

Multivalent interactions essential for lentiviral integrase function.