Nicolas Servant

PRC2 is dispensable for -mediated transcriptional repression.

Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing's syndrome.

VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles.

High-resolution mapping of DNA breakpoints to define true recurrences among ipsilateral breast cancers.

Tumor aromatase expression as a prognostic factor for local control in young breast cancer patients after breast-conserving treatment.

Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production.

Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation.

LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.

EMA - A R package for Easy Microarray data analysis.

Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients.

Search for a gene expression signature of breast cancer local recurrence in young women.

Deep-sequencing protocols influence the results obtained in small-RNA sequencing.

Spatial partitioning of the regulatory landscape of the X-inactivation centre.

Independent transcriptional reprogramming and apoptosis induction by cisplatin.

HiTC: exploration of high-throughput 'C' experiments.

ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data.

Designs and challenges for personalized medicine studies in oncology: focus on the SHIVA trial.

Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.

RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells.

Changes in the organization of the genome during the mammalian cell cycle.

Developmental dynamics and disease potential of random monoallelic gene expression.

Combinatorial flexibility of cytokine function during human T helper cell differentiation.

Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial.

[Biological network modelling and precision medicine in oncology].

Multi-factor data normalization enables the detection of copy number aberrations in amplicon sequencing data.

Epigenomic alterations in breast carcinoma from primary tumor to locoregional recurrences.

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

The spectrum of clinical trials aiming at personalizing medicine.

Combinatorial code governing cellular responses to complex stimuli.

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.

DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial.

Design and statistical principles of the SHIVA trial.

Integration of a Radiosensitivity Molecular Signature Into the Assessment of Local Recurrence Risk in Breast Cancer.

Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials.

HiC-Pro: an optimized and flexible pipeline for Hi-C data processing.

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis.

Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation.

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations.

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass.

Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma.

Revisited analysis of a SHIVA01 trial cohort using functional mutational analyses successfully predicted treatment outcome.

Challenges for the implementation of high-throughput testing and liquid biopsies in personalized medicine cancer trials.

Transcriptome Profiling of Single Mouse Oocytes.

Effective normalization for copy number variation in Hi-C data.

Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing.

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.

Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells.

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.

Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome.

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular Targets.

Improving breast cancer sensitivity to paclitaxel by increasing aneuploidy.

Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.

A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary.

Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas.

Parental-to-embryo switch of chromosome organization in early embryogenesis.

Corrigendum to 'clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome'.

CD44 regulates epigenetic plasticity by mediating iron endocytosis.

Bioinformatic Analysis of Single-Cell Hi-C Data from Early Mouse Embryo.

Interactive analysis of single-cell epigenomic landscapes with ChromSCape.

Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.

SMARCA4-deficient rhabdoid tumours show intermediate molecular features between SMARCB1-deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type.

A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial.

Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma.

Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication.

Bioinformatics Methods for ChIP-seq Histone Analysis.

Compartment-specific and ELAVL1-coordinated regulation of intronic polyadenylation isoforms by doxorubicin.

Genomics to select treatment for patients with metastatic breast cancer.