Adam D. Bachstetter

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα.

The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.

Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models.

The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease.

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.

Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain.

Diffuse brain injury induces acute post-traumatic sleep.

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.

Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.

Generation and behavior characterization of CaMKIIβ knockout mice.

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism.

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging.

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury.

Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury.

Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.

Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.

Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.

Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.

A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism.

Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.

Simulation of P2X-mediated calcium signalling in microglia.

Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats.

Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice.

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.

Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.

The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review.

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice.

An active avoidance behavioral paradigm for use in a mild closed head model of traumatic brain injury in mice.

Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury.

Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases.

Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.

Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review.

Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1.

Dysregulation of Systemic Immunity in Aging and Dementia.

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities.

Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase.