Spinal Cord & Brain Injury Research Center,
Department of Neuroscience,
Sanders-Brown Center on Aging
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CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.
Journal of neuroinflammation Jan, 2011 | Pubmed ID: 21266082
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).
Journal of neuroinflammation Jul, 2011 | Pubmed ID: 21733175
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα.
Molecular neurodegeneration Dec, 2011 | Pubmed ID: 22185458
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.
Aging and disease Dec, 2010 | Pubmed ID: 22720195
Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2012 | Pubmed ID: 22836255
Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2012 | Pubmed ID: 23152597
Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models.
PloS one , 2013 | Pubmed ID: 23457629
The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2013 | Pubmed ID: 23554495
Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease.
Alzheimer's research & therapy , 2013 | Pubmed ID: 23705774
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
PloS one , 2013 | Pubmed ID: 23840427
Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain.
Journal of neuroinflammation Dec, 2013 | Pubmed ID: 24314267
Diffuse brain injury induces acute post-traumatic sleep.
PloS one , 2014 | Pubmed ID: 24416145
Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Sep, 2014 | Pubmed ID: 24789302
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.
Frontiers in genetics , 2014 | Pubmed ID: 24795750
Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.
Journal of molecular neuroscience : MN Feb, 2015 | Pubmed ID: 25012593
Generation and behavior characterization of CaMKIIβ knockout mice.
PloS one , 2014 | Pubmed ID: 25127391
The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism.
Journal of neuroinflammation Oct, 2014 | Pubmed ID: 25297465
Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.
Journal of neuroinflammation Apr, 2015 | Pubmed ID: 25886256
Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2015 | Pubmed ID: 25904805
Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging.
Acta neuropathologica communications May, 2015 | Pubmed ID: 26001591
Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury.
Journal of neuroinflammation Sep, 2015 | Pubmed ID: 26329692
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 01, 2017 | Pubmed ID: 26738751
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.
PloS one , 2016 | Pubmed ID: 26871438
Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury.
Journal of neurotrauma Jan, 2017 | Pubmed ID: 27142118
Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.
Molecular pain , 2016 | Pubmed ID: 27178244
Targeting innate immunity for neurodegenerative disorders of the central nervous system.
Journal of neurochemistry Sep, 2016 | Pubmed ID: 27248001
Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.
Neurobiology of aging 04, 2017 | Pubmed ID: 28131016
Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.
Brain pathology (Zurich, Switzerland) 03, 2018 | Pubmed ID: 28281308
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.
Journal of neuroinflammation 04, 2017 | Pubmed ID: 28381303
Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.
Journal of neuroinflammation May, 2018 | Pubmed ID: 29789012
A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism.
Journal of neurotrauma 10, 2018 | Pubmed ID: 29808778
Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.
Neural regeneration research Oct, 2018 | Pubmed ID: 30136679
Simulation of P2X-mediated calcium signalling in microglia.
The Journal of physiology 02, 2019 | Pubmed ID: 30462840
Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.
Neuroscience 02, 2019 | Pubmed ID: 30529693
A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats.
Journal of neurotrauma 06, 2019 | Pubmed ID: 30661454
Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice.
Alzheimer's & dementia (New York, N. Y.) , 2019 | Pubmed ID: 30859123
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
GeroScience 10, 2019 | Pubmed ID: 31104189
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.
Journal of neuropathology and experimental neurology 01, 2020 | Pubmed ID: 31748784
The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review.
Experimental neurology 04, 2020 | Pubmed ID: 31930992
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice.
Journal of neuroinflammation Apr, 2020 | Pubmed ID: 32290848
An active avoidance behavioral paradigm for use in a mild closed head model of traumatic brain injury in mice.
Journal of neuroscience methods 09, 2020 | Pubmed ID: 32592717
Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury.
PloS one , 2020 | Pubmed ID: 32810143
Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases.
Journal of neurotrauma 05, 2021 | Pubmed ID: 33297844
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.
Neurobiology of aging 03, 2021 | Pubmed ID: 33422891
Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review.
Acta neuropathologica communications 03, 2021 | Pubmed ID: 33757579
Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1.
Frontiers in immunology , 2021 | Pubmed ID: 34093593
Dysregulation of Systemic Immunity in Aging and Dementia.
Frontiers in cellular neuroscience , 2021 | Pubmed ID: 34239415
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities.
Nature reviews. Endocrinology 01, 2022 | Pubmed ID: 34703027
Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase.
Journal of cellular immunology , 2022 | Pubmed ID: 35611116
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