Rosalie C Sears

The life cycle of C-myc: from synthesis to degradation.

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.

Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress.

PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells.

Studying c-Myc serine 62 phosphorylation in leukemia cells: concern over antibody cross-reactivity.

A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence.

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

Diminished WNT -> β-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors.

MYC degradation.

Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.

Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer.

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity.

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.

Deubiquitinating c-Myc: USP36 steps up in the nucleolus.

Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.

The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase.

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers.

Serum Biomarker Signature-Based Liquid Biopsy for Diagnosis of Early-Stage Pancreatic Cancer.

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer.

SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting.

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression.

Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer.

The use of protein phosphatase 2A activators in combination therapies for pancreas cancer.

Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming.

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer.

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity.

Writing and erasing MYC ubiquitination and SUMOylation.

Deconstructing Pancreatic Adenocarcinoma by Targeting the Conductor, MYC.

PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals.

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer.

Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer.

Hypoxia: Friend or Foe for drug delivery in Pancreatic Cancer.

Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma.

Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome.

The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis.

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

Loss of Ambra1 promotes melanoma growth and invasion.

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.

Detection of Post-translational Modifications on MYC.

Tumor-Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients With Pancreatic Adenocarcinoma.

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy.

Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics.

High-content single-cell combinatorial indexing.

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies.

T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62.

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms.

Microfluidics Formulated Liposomes of Hypoxia Activated Prodrug for Treatment of Pancreatic Cancer.

The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma.

Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.

A path to translation: How 3D patient tumor avatars enable next generation precision oncology.

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

Deletion of the mRNA stability factor (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity.

MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.

Unraveling MYC's Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance.

Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility.

Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment.