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Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

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01:31 min

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February 2nd, 2024

DOI :

10.3791/65811-v

February 2nd, 2024

•

458 Views

Amani Alshaikh¹^,², Dmytro Grygoryev³, Dove Keith⁴, Brett Sheppard⁴^,⁵, Rosalie C Sears⁴^,⁶, Jungsun Kim³^,⁶, Abdenour Soufi¹

¹Centre for Regenerative Medicine, Institute of Regeneration and Repair, Institute of Stem Cell Research, The University of Edinburgh, ²King Abdulaziz City for Science and Technology Health Sector (KACST), ³Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, ⁴Brenden-Colson Canter for Pancreatic Care, Oregon Health & Science University, ⁵Department of Surgery, Oregon Health & Science University, ⁶Department of Molecular & Medical Genetics, Oregon Health & Science University

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Keywords Pancreatic Ductal Adenocarcinoma

Induced Pluripotent Stem Cells

IPSC Reprogramming

Cancer Epigenome

Pancreatic Intraepithelial Neoplasia

Early detection Diagnostic Markers

Bicistronic Lentiviral Vectors

PDAC derived IPSCs

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