Cecilia M. Giachelli

NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival.

Ectopic calcification: gathering hard facts about soft tissue mineralization.

Effects of cyclosporine in osteopontin null mice.

Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo.

Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification.

Immunohistologic labeling of murine endothelium.

Vascular calcification: in vitro evidence for the role of inorganic phosphate.

Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces.

Characterization and analysis of osteopontin-immobilized poly(2-hydroxyethyl methacrylate) surfaces.

Expression and function of the integrin alpha9beta1 in bovine aortic valve interstitial cells.

Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials.

Regulation of cardiovascular calcification.

Enhancing the biological activity of immobilized osteopontin using a type-1 collagen affinity coating.

Hyaluronic acid grafting mitigates calcification of glutaraldehyde-fixed bovine pericardium.

Mechanisms of vascular calcification in uremia.

Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro.

The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.

Vascular calcification mechanisms.

Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB.

Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.

Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin.

Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro.

Regulation of vascular calcification: roles of phosphate and osteopontin.

Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells.

Esophageal epithelial cell interaction with synthetic and natural scaffolds for tissue engineering.

Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion.

The role of osteopontin in foreign body giant cell formation.

Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells.

Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: current concepts at the bench.

Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification.

Development of an esophagus acellular matrix tissue scaffold.

Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation.

Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice.

Molecular mediators of alphavbeta3-induced endothelial cell survival.

Mechanisms of vascular calcification.

Sodium-dependent phosphate cotransporters and vascular calcification.

Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression.

Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease.

A fibrinogen-based precision microporous scaffold for tissue engineering.

BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.

Role of carbonic anhydrase II in ectopic calcification.

The influence of surface mineral and osteopontin on the formation and function of murine bone marrow-derived osteoclasts.

Crosslinking of an oesophagus acellular matrix tissue scaffold.

Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering.

Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model.

Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function.

The emerging role of phosphate in vascular calcification.

Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries.

Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin.

Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering.

The role of osteopontin in inflammatory processes.

Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1.

Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization.

Vitamin D receptor activators induce an anticalcific paracrine program in macrophages: requirement of osteopontin.

Characterization of mandibular bone in a mouse model of chronic kidney disease.

Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis.

Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1.

Matrix remodeling in vascular calcification associated with chronic kidney disease.

Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.

Direct effects of phosphate on vascular cell function.

Arterial calcification in chronic kidney disease: key roles for calcium and phosphate.

Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells.

Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study.

Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts.

Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.

RANKL enhances macrophage paracrine pro-calcific activity in high phosphate-treated smooth muscle cells: dependence on IL-6 and TNF-α.

High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease.

Smooth muscle cell plasticity: fact or fiction?

Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.

Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications.

Fibroblast growth factor 23 is not associated with and does not induce arterial calcification.

Vascular calcification: an update on mechanisms and challenges in treatment.

Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.

An inducible, ligand-independent receptor activator of NF-κB gene to control osteoclast differentiation from monocytic precursors.

Engineered biomaterials control differentiation and proliferation of human-embryonic-stem-cell-derived cardiomyocytes via timed Notch activation.

Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.

A current understanding of vascular calcification in CKD.

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.

Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice.

SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification.

Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells.

Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification.

Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation.

Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho.

Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice.

Noncanonical Wnts at the Cusp of Fibrocalcific Signaling Processes in Human Calcific Aortic Valve Disease.

Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.

Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLrApoB mouse model.

PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.

Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.

Engineered osteoclasts resorb necrotic alveolar bone in anti-RANKL antibody-treated mice.

Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models.

Dissecting specific Wnt components governing osteogenic differentiation potential by human periodontal ligament stem cells through interleukin-6.

Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins.

Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins.