Arnold J. Levine

WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.

p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.

Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

Stochastic gene expression in a single cell.

Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation.

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Dynamics of the p53-Mdm2 feedback loop in individual cells.

P53 is a tumor suppressor gene.

Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis.

Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: a directional link between NF-kappaB and p53.

Tissue-specific codon usage and the expression of human genes.

Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.

In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.

MDM2 is a central node in the p53 pathway: 12 years and counting.

Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.

The p53 pathway: positive and negative feedback loops.

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.

The coordinate regulation of the p53 and mTOR pathways in cells.

A plausible model for the digital response of p53 to DNA damage.

The contribution of the Trp/Met/Phe residues to physical interactions of p53 with cellular proteins.

Detection of functional single-nucleotide polymorphisms that affect apoptosis.

A relative-entropy algorithm for genomic fingerprinting captures host-phage similarities.

A robust meta-classification strategy for cancer detection from MS data.

Robust diagnosis of non-Hodgkin lymphoma phenotypes validated on gene expression data from different laboratories.

A robust meta-classification strategy for cancer diagnosis from gene expression data.

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.

Comparison of the human and worm p53 structures suggests a way for enhancing stability.

The regulation of exosome secretion: a novel function of the p53 protein.

MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.

MDM2 SNP309 accelerates colorectal tumour formation in women.

Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes.

Haplotype structure and selection of the MDM2 oncogene in humans.

A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.

Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets.

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.

Reconstructing signal transduction pathways: challenges and opportunities.

Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements.

High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates.

p53 regulates maternal reproduction through LIF.

Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging.

Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency.

An information-theoretic analysis of genetics, gender and age in cancer patients.

The computational detection of functional nucleotide sequence motifs in the coding regions of organisms.

The tumor suppressor p53: cancer and aging.

p53: a new player in reproduction.

Patterns of evolution and host gene mimicry in influenza and other RNA viruses.

Anomalies in the influenza virus genome database: new biology or laboratory errors?

A recoding method to improve the humoral immune response to an HIV DNA vaccine.

Why do we not yet have a human immunodeficiency virus vaccine?

P53 mutations in lymphomas: position matters.

The genetics of the p53 pathway, apoptosis and cancer therapy.

The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.

The regulation of the endosomal compartment by p53 the tumor suppressor gene.

Non-random reassortment in human influenza A viruses.

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.

Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system.

A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.

Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival.

The first 30 years of p53: growing ever more complex.

Stem cell biology meets p53.

One billion years of p53/p63/p73 evolution.

The regulation of human reproduction by p53 and its pathway.

Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival.

Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.

Germline mutations and polymorphisms in the origins of cancers in women.

Higher order Boolean networks as models of cell state dynamics.

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.

Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome.

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma.

The origins and evolution of the p53 family of genes.

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism.

Negative regulation of tumor suppressor p53 by microRNA miR-504.

Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.

A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.

Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes.

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.

Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old.

Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway.

Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes.

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.

Regulation of female reproduction by p53 and its family members.

The p53 family: guardians of maternal reproduction.

Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival.

Monographs editor.

Introduction: The Changing Directions of p53 Research.

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.

Molecular classification of prostate cancer using curated expression signatures.

The evolution of the p53 family of genes.

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

Viral reassortment as an information exchange between viral segments.

Chronic restraint stress attenuates p53 function and promotes tumorigenesis.

Allele-specific p53 mutant reactivation.

Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers.

Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk4/Cdk6.

A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets.