The Cancer Institute of New Jersey
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WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.
Genes & development Jan, 2002 | Pubmed ID: 11782444
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.
Genes & development Apr, 2002 | Pubmed ID: 11959846
Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
Oncogene Jul, 2002 | Pubmed ID: 12096336
Stochastic gene expression in a single cell.
Science (New York, N.Y.) Aug, 2002 | Pubmed ID: 12183631
Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation.
The Journal of biological chemistry Mar, 2003 | Pubmed ID: 12529380
CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.
Genes & development Feb, 2003 | Pubmed ID: 12569127
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2003 | Pubmed ID: 12972634
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2003 | Pubmed ID: 14657337
Dynamics of the p53-Mdm2 feedback loop in individual cells.
Nature genetics Feb, 2004 | Pubmed ID: 14730303
P53 is a tumor suppressor gene.
Cell Jan, 2004 | Pubmed ID: 15055586
Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2004 | Pubmed ID: 15184680
Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: a directional link between NF-kappaB and p53.
Cell cycle (Georgetown, Tex.) Aug, 2004 | Pubmed ID: 15280657
Tissue-specific codon usage and the expression of human genes.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2004 | Pubmed ID: 15314228
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.
Cancer cell Oct, 2004 | Pubmed ID: 15488761
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Cell Nov, 2004 | Pubmed ID: 15550242
In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.
Biochemistry Feb, 2005 | Pubmed ID: 15683227
MDM2 is a central node in the p53 pathway: 12 years and counting.
Current cancer drug targets Feb, 2005 | Pubmed ID: 15720184
Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2005 | Pubmed ID: 15738397
The p53 pathway: positive and negative feedback loops.
Oncogene Apr, 2005 | Pubmed ID: 15838523
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15908423
The coordinate regulation of the p53 and mTOR pathways in cells.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2005 | Pubmed ID: 15928081
A plausible model for the digital response of p53 to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2005 | Pubmed ID: 16186499
The contribution of the Trp/Met/Phe residues to physical interactions of p53 with cellular proteins.
Physical biology Jun, 2005 | Pubmed ID: 16204849
Detection of functional single-nucleotide polymorphisms that affect apoptosis.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2005 | Pubmed ID: 16260726
A relative-entropy algorithm for genomic fingerprinting captures host-phage similarities.
Journal of bacteriology Dec, 2005 | Pubmed ID: 16321941
A robust meta-classification strategy for cancer detection from MS data.
Proteomics Jan, 2006 | Pubmed ID: 16342141
Robust diagnosis of non-Hodgkin lymphoma phenotypes validated on gene expression data from different laboratories.
Genome informatics. International Conference on Genome Informatics , 2005 | Pubmed ID: 16362926
A robust meta-classification strategy for cancer diagnosis from gene expression data.
Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference , 2005 | Pubmed ID: 16447989
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways.
Genes & development Feb, 2006 | Pubmed ID: 16452501
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.
Nature reviews. Cancer Mar, 2006 | Pubmed ID: 16453012
Comparison of the human and worm p53 structures suggests a way for enhancing stability.
Biochemistry Mar, 2006 | Pubmed ID: 16548519
The regulation of exosome secretion: a novel function of the p53 protein.
Cancer research May, 2006 | Pubmed ID: 16651434
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.
Cancer research May, 2006 | Pubmed ID: 16707433
MDM2 SNP309 accelerates colorectal tumour formation in women.
Journal of medical genetics Dec, 2006 | Pubmed ID: 16825430
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes.
Journal of virology Dec, 2006 | Pubmed ID: 16987977
Haplotype structure and selection of the MDM2 oncogene in humans.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2007 | Pubmed ID: 17360557
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.
Cancer research Mar, 2007 | Pubmed ID: 17363597
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer research Apr, 2007 | Pubmed ID: 17409411
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets.
Nucleic acids research , 2007 | Pubmed ID: 17439973
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17921246
Reconstructing signal transduction pathways: challenges and opportunities.
Annals of the New York Academy of Sciences Dec, 2007 | Pubmed ID: 17934060
Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements.
Nucleic acids research , 2007 | Pubmed ID: 17986463
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates.
Cancer research Nov, 2007 | Pubmed ID: 18006808
p53 regulates maternal reproduction through LIF.
Nature Nov, 2007 | Pubmed ID: 18046411
Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging.
Journal of virology Mar, 2008 | Pubmed ID: 18094182
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2008 | Pubmed ID: 18378902
An information-theoretic analysis of genetics, gender and age in cancer patients.
PloS one , 2008 | Pubmed ID: 18398474
The computational detection of functional nucleotide sequence motifs in the coding regions of organisms.
Experimental biology and medicine (Maywood, N.J.) Jun, 2008 | Pubmed ID: 18408149
The tumor suppressor p53: cancer and aging.
Cell cycle (Georgetown, Tex.) Apr, 2008 | Pubmed ID: 18414039
p53: a new player in reproduction.
Cell cycle (Georgetown, Tex.) Apr, 2008 | Pubmed ID: 18414047
Patterns of evolution and host gene mimicry in influenza and other RNA viruses.
PLoS pathogens Jun, 2008 | Pubmed ID: 18535658
Anomalies in the influenza virus genome database: new biology or laboratory errors?
Journal of virology Sep, 2008 | Pubmed ID: 18579605
A recoding method to improve the humoral immune response to an HIV DNA vaccine.
PloS one , 2008 | Pubmed ID: 18791646
Why do we not yet have a human immunodeficiency virus vaccine?
Journal of virology Dec, 2008 | Pubmed ID: 18829744
P53 mutations in lymphomas: position matters.
Blood Oct, 2008 | Pubmed ID: 18840714
The genetics of the p53 pathway, apoptosis and cancer therapy.
Nature reviews. Drug discovery Dec, 2008 | Pubmed ID: 19043449
The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.
Virology Feb, 2009 | Pubmed ID: 19081592
The regulation of the endosomal compartment by p53 the tumor suppressor gene.
The FEBS journal Apr, 2009 | Pubmed ID: 19302216
Non-random reassortment in human influenza A viruses.
Influenza and other respiratory viruses Jan, 2008 | Pubmed ID: 19453489
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2009 | Pubmed ID: 19470478
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2009 | Pubmed ID: 19497887
Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system.
PloS one , 2009 | Pubmed ID: 19536338
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.
Carcinogenesis Nov, 2009 | Pubmed ID: 19762336
Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2009 | Pubmed ID: 19773383
The first 30 years of p53: growing ever more complex.
Nature reviews. Cancer Oct, 2009 | Pubmed ID: 19776744
Stem cell biology meets p53.
Nature biotechnology Oct, 2009 | Pubmed ID: 19816447
One billion years of p53/p63/p73 evolution.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2009 | Pubmed ID: 19826090
The regulation of human reproduction by p53 and its pathway.
Cell cycle (Georgetown, Tex.) Nov, 2009 | Pubmed ID: 19884797
Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival.
Cancer research Jan, 2010 | Pubmed ID: 19996285
Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2010 | Pubmed ID: 20019240
Germline mutations and polymorphisms in the origins of cancers in women.
Journal of oncology , 2010 | Pubmed ID: 20111735
Higher order Boolean networks as models of cell state dynamics.
Journal of theoretical biology Jun, 2010 | Pubmed ID: 20303985
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
Trends in cell biology Jul, 2010 | Pubmed ID: 20399660
Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome.
BMC genetics , 2010 | Pubmed ID: 20416085
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma.
BMC systems biology , 2010 | Pubmed ID: 20420713
The origins and evolution of the p53 family of genes.
Cold Spring Harbor perspectives in biology Jun, 2010 | Pubmed ID: 20516129
p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2010 | Pubmed ID: 20530750
Negative regulation of tumor suppressor p53 by microRNA miR-504.
Molecular cell Jun, 2010 | Pubmed ID: 20542001
Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.
Breast cancer research and treatment Feb, 2011 | Pubmed ID: 20658316
A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.
International journal of cancer. Journal international du cancer May, 2011 | Pubmed ID: 20669227
Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes.
PLoS pathogens , 2010 | Pubmed ID: 20686665
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Cancer cell Sep, 2010 | Pubmed ID: 20832750
Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old.
Journal of virology Dec, 2010 | Pubmed ID: 20861255
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway.
Genes & cancer May, 2010 | Pubmed ID: 20871795
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes.
Genes & cancer Feb, 2010 | Pubmed ID: 20948976
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.
Science (New York, N.Y.) Dec, 2010 | Pubmed ID: 21127244
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2010 | Pubmed ID: 21149740
Regulation of female reproduction by p53 and its family members.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul, 2011 | Pubmed ID: 21402718
The p53 family: guardians of maternal reproduction.
Nature reviews. Molecular cell biology Apr, 2011 | Pubmed ID: 21427767
Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2011 | Pubmed ID: 21482760
Monographs editor.
Genes & cancer Apr, 2011 | Pubmed ID: 21779506
Introduction: The Changing Directions of p53 Research.
Genes & cancer Apr, 2011 | Pubmed ID: 21785490
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2011 | Pubmed ID: 21930938
Molecular classification of prostate cancer using curated expression signatures.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22123976
The evolution of the p53 family of genes.
Cell cycle (Georgetown, Tex.) Jan, 2012 | Pubmed ID: 22214668
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Cell Jan, 2012 | Pubmed ID: 22265415
Viral reassortment as an information exchange between viral segments.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2012 | Pubmed ID: 22331898
Chronic restraint stress attenuates p53 function and promotes tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22509031
Allele-specific p53 mutant reactivation.
Cancer cell May, 2012 | Pubmed ID: 22624712
Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers.
PloS one , 2012 | Pubmed ID: 22719901
Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk4/Cdk6.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2012 | Pubmed ID: 22761470
A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets.
Molecular cancer therapeutics Aug, 2012 | Pubmed ID: 22863609
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