Paul Gadue

Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia

Affiliated withChildren's Hospital of Philadelphia The Children's Hospital of Philadelphia University of Pennsylvania

Research Area

BiologyGenetics

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2012
Publication title	2019

Other Publications

Article	Year
NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12193707	2002
The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. European journal of immunology\| PubMed ID: 12884290	2003
Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15128794	2004
Germ layer induction from embryonic stem cells. Experimental hematology\| PubMed ID: 16140142	2005
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17077151	2006
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nature biotechnology\| PubMed ID: 17086172	2006
Identification and targeting of the ROSA26 locus in human embryonic stem cells. Nature biotechnology\| PubMed ID: 18037879	2007
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell stem cell\| PubMed ID: 18371422	2008
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (Cambridge, England)\| PubMed ID: 18799543	2008
Epidermal cells rev up reprogramming. Nature biotechnology\| PubMed ID: 18997762	2008
Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. Stem cells (Dayton, Ohio)\| PubMed ID: 19522011	2009
Stem cells unscramble yolk sac hematopoiesis. Blood\| PubMed ID: 19696206	2009
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes & development\| PubMed ID: 20008934	2009
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem cells (Dayton, Ohio)\| PubMed ID: 20715179	2010
Liver regeneration from induced pluripotent stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21119691	2010
A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells. Stem cell research\| PubMed ID: 21169079	2011
Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. The Journal of clinical investigation\| PubMed ID: 21537085	2011
An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling. Stem cells (Dayton, Ohio)\| PubMed ID: 21732480	2011
High-throughput screening assay for embryoid body differentiation of human embryonic stem cells. Current protocols in stem cell biology\| PubMed ID: 22415836	2012
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell stem cell\| PubMed ID: 22482503	2012
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23045704	2012
AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. PloS one\| PubMed ID: 23667438	2013
Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients. Blood\| PubMed ID: 23744582	2013
Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. Blood\| PubMed ID: 23940280	2013
High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood\| PubMed ID: 24335497	2014
The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells. Stem cell research\| PubMed ID: 24412757	2014
Utilization of the AAVS1 safe harbor locus for hematopoietic specific transgene expression and gene knockdown in human ES cells. Stem cell research\| PubMed ID: 24631742	2014
Hematopoietic differentiation of pluripotent stem cells in culture. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25062629	2014
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus. The Journal of clinical investigation\| PubMed ID: 25621499	2015
A Doxycycline-Inducible System for Genetic Correction of iPSC Disease Models. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25630922	2016
Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem cell reports\| PubMed ID: 25843048	2015
Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. Blood\| PubMed ID: 25852052	2015
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of clinical investigation\| PubMed ID: 25961454	2015
OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm. Stem cell reports\| PubMed ID: 26411902	2015
Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs). Stem cell research\| PubMed ID: 26987923	2015
Generation of human control iPS cell line CHOPWT9 from healthy adult peripheral blood mononuclear cells. Stem cell research\| PubMed ID: 27345777	2016
Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) induced pluripotent stem cells (iPSCs). Stem cell research\| PubMed ID: 27345974	2016
Generation of Hermansky Pudlak syndrome type 2 (HPS2) induced pluripotent stem cells (iPSCs). Stem cell research\| PubMed ID: 27345985	2016
Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells. Stem cell research\| PubMed ID: 27345999	2016
GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells. Stem cell reports\| PubMed ID: 28196690	2017
Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28982668	2017
Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain. Neuroscience\| PubMed ID: 29289717	2018
GATA6 suppression enhances lung specification from human pluripotent stem cells. The Journal of clinical investigation\| PubMed ID: 29889101	2018
Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL. Stem cell research\| PubMed ID: 30096712	2018
Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells. Current protocols in stem cell biology\| PubMed ID: 30358158	2019
Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. Stem cell research\| PubMed ID: 30611021	2019
Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. Cell stem cell\| PubMed ID: 31374199	2019