Aras Kadioglu

Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection.

Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.

Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae.

Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils.

The innate immune response to pneumococcal lung infection: the untold story.

Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae.

CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts.

Susceptibility and resistance to pneumococcal disease in mice.

Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.

Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis.

The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.

MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands.

The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae.

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.

Increased TNF expression in CD43++ murine blood monocytes.

Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.

Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae.

The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.

Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14.

Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin.

A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection.

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection.

Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation.

Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice.

Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections.

Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.

Capsule type of Streptococcus pneumoniae determines growth phenotype.

P4-mediated antibody therapy in an acute model of invasive pneumococcal disease.

T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.

Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses.

Gene expression in fungi.

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B.

Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults.

The AgI/II family adhesin AspA is required for respiratory infection by Streptococcus pyogenes.

Immunoactivating peptide p4 augments alveolar macrophage phagocytosis in two diverse human populations.

The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract.

Streptococcus pneumoniae detects and responds to foreign bacterial peptide fragments in its environment.

Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells.

The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa.

Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.

Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins.

Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice.

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection.

Alternatives to antibiotics-a pipeline portfolio review.

Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis.

Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule.

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

Phage therapy is highly effective against chronic lung infections with .

Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus 32.2 Outbreak.

The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation.

Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia.

Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation.

E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

Erratum for Graham-Brown et al., "Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation".

Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.

Erratum for Cornick et al., "Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus 32.2 Outbreak".

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.

Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data.

Impaired Alanine Transport or Exposure to d-Cycloserine Increases the Susceptibility of MRSA to β-lactam Antibiotics.

IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue.

Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease.

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin.

Influenza-like illness is associated with high pneumococcal carriage density in Malawian children.

Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.

Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.

Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes.

Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.

Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease.

Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms.

Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.

Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors.

Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission.

Selection of in a murine nasopharyngeal colonization model.

Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo.

Intranasal administration of DSM 32444 spores: safety and tolerability.

Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse Pseudomonas aeruginosa from Cystic Fibrosis Patients.

Airborne dust and high temperatures are risk factors for invasive bacterial disease.

Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections.

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection.

Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci.

Underground railway particulate matter and susceptibility to pneumococcal infection.

Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance.

The LytSR two-component regulatory system promotes vaginal colonization and virulence .