Dobromir Dobrev

Problem-based learning: a new pathway to competence?

Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation.

What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy".

Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test.

Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum.

Cardiac sympathetic innervation and control of potassium channel function.

Remodeling of cardiomyocyte ion channels in human atrial fibrillation.

Transcription factors for ion channels: active or passive players in cardiac remodeling?

Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation.

Mechanisms of beta-adrenergic receptor-mediated venodilation in humans.

Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation?

Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation.

An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit.

Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo?

Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencing.

Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes.

Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays.

Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.

Electrical remodeling in atrial fibrillation.

Do genetics help to better understand the underlying mechanisms of atrial fibrillation?

Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.

Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.

5-hydroxytryptamine and atrial arrhythmogenesis: a "culprit mechanism" or bystander in patients with chronic atrial fibrillation?

Novel anti-arrhythmic agents for the treatment of atrial fibrillation.

Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation.

Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure.

Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation.

Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential.

Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis?

Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes.

Bootstrapped two-electrode biosignal amplifier.

New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillation.

Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis.

Digital lock-in techniques for adaptive power-line interference extraction.

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.

Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current.

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics.

Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis.

Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.

The German Competence Network on Atrial Fibrillation (AFNET).

Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles.

Ion channel portrait of the human sinus node: useful for a better understanding of sinus node function and dysfunction in humans?

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation.

Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target.

Atrial remodeling and atrial fibrillation: mechanisms and implications.

Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure.

Animal models for atrial fibrillation: clinical insights and scientific opportunities.

Stroke prevention versus bleeding risk of vitamin-K antagonists: a double-edged sword in patients with atrial fibrillation who require surgery.

Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.

New antiarrhythmic drugs for treatment of atrial fibrillation.

Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation.

Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation.

Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.

Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation.

The impact of rapid atrial pacing on ADMA and endothelial NOS.

The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.

Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart.

Vernakalant.

Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium.

Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model.

New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications.

Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling.

Atrial-selective sodium channel block by dronedarone: sufficient to terminate atrial fibrillation?

Prevention of atrial fibrillation complications with antiarrhythmic drugs: still an unmet need in clinical practice.

Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.

No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population.

Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.

Oxidized CaMKII causes cardiac sinus node dysfunction in mice.

Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference.

Recent advances in the molecular pathophysiology of atrial fibrillation.

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.

Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling.

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation.

Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice.

Proarrhythmic atrial calcium cycling in the diseased heart.

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.

Novel molecular targets for atrial fibrillation therapy.

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities.

Role of RyR2 phosphorylation at S2814 during heart failure progression.

Calcium handling and atrial fibrillation.

Systems approaches to post-operative atrial fibrillation - do they help us to better understand the ionic basis of the arrhythmogenic substrate?

Is altered atrial microRNA-ome a critical contributor to the pathophysiology of atrial fibrillation?

Palmitoylation and membrane association of the stress axis regulated insert (STREX) controls BK channel regulation by protein kinase C.

Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation.

Voltage-gated Na⁺ channels: novel players in fibroblast-to-myofibroblast transition with a potential role in atrial arrhythmogenesis?

Cellular and molecular correlates of ectopic activity in patients with atrial fibrillation.

The biology of human pulmonary veins: does it help us to better understand AF pathophysiology in patients?

New directions in antiarrhythmic drug therapy for atrial fibrillation.

Electrical storm: recent pathophysiological insights and therapeutic consequences.

MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation.

Impaired Na(+)-dependent regulation of acetylcholine-activated inward-rectifier K(+) current modulates action potential rate dependence in patients with chronic atrial fibrillation.

Pleiotropic actions of amiodarone: still puzzling after half a century.

Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model.

KCNQ1 autoantibodies: another way to regulate IKs.

Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update.

Phosphodiesterase-2 is Upregulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes.