Wolfgang Wiechert

Modeling and simulation: tools for metabolic engineering.

An introduction to 13C metabolic flux analysis.

MMT--a pathway modeling tool for data from rapid sampling experiments.

Metabolic isotopomer labeling systems. Part II: structural flux identifiability analysis.

New tools for mass isotopomer data evaluation in (13)C flux analysis: mass isotope correction, data consistency checking, and precursor relationships.

Serial 13C-based flux analysis of an L-phenylalanine-producing E. coli strain using the sensor reactor.

Investigating the dynamic behavior of biochemical networks using model families.

From stationary to instationary metabolic flux analysis.

Emerging Corynebacterium glutamicum systems biology.

Interpretation of metabolic flux maps by limitation potentials and constrained limitation sensitivities.

Experimental design principles for isotopically instationary 13C labeling experiments.

Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions.

Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments.

Nondestructive and noncontact method for determining the spring constant of rectangular cantilevers.

Fluxomics: mass spectrometry versus quantitative imaging.

The thermodynamic meaning of metabolic exchange fluxes.

The topology of metabolic isotope labeling networks.

Visualizing regulatory interactions in metabolic networks.

13C labeling experiments at metabolic nonstationary conditions: an exploratory study.

Translating biochemical network models between different kinetic formats.

Modeling Languages for Biochemical Network Simulation: Reaction vs Equation Based Approaches.

Stationary versus non-stationary (13)C-MFA: a comparison using a consistent dataset.

Mechanistic pathway modeling for industrial biotechnology: challenging but worthwhile.

Visualizing multi-omics data in metabolic networks with the software Omix: a case study.

The benefits of being transient: isotope-based metabolic flux analysis at the short time scale.

Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient, L-valine-producing Corynebacterium glutamicum.

Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of ¹³C metabolic flux analysis.

Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells.

Tailoring a stabilized variant of hydroxynitrile lyase from Arabidopsis thaliana.

A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level.

Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments.

Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms.

13CFLUX2--high-performance software suite for (13)C-metabolic flux analysis.

Influence of Organic Solvents on Enzymatic Asymmetric Carboligations.

Combined fluxomics and transcriptomics analysis of glucose catabolism via a partially cyclic pentose phosphate pathway in Gluconobacter oxydans 621H.

Metabolic isotopomer labeling systems. Part III: path tracing.

Isotopically non-stationary metabolic flux analysis: complex yet highly informative.

Simultaneous utilization of glucose and gluconate in Penicillium chrysogenum during overflow metabolism.

13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis.

Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.

Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes.

Assessment of robustness against dissolved oxygen/substrate oscillations for C. glutamicum DM1933 in two-compartment bioreactor.

Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum.

Single-cell microfluidics: opportunity for bioprocess development.

Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer.

Quantitative metabolomics: a phantom?

Error propagation analysis for quantitative intracellular metabolomics.

Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum.

An evaluation of genetically encoded FRET-based biosensors for quantitative metabolite analyses in vivo.

Chassis organism from Corynebacterium glutamicum--a top-down approach to identify and delete irrelevant gene clusters.

Visual workflows for 13C-metabolic flux analysis.

Engineering of Corynebacterium glutamicum for minimized carbon loss during utilization of D-xylose containing substrates.

Absolute quantification of Corynebacterium glutamicum glycolytic and anaplerotic enzymes by QconCAT.

How to measure metabolic fluxes: a taxonomic guide for (13)C fluxomics.

Bioprocess automation on a Mini Pilot Plant enables fast quantitative microbial phenotyping.

The effect of composition on diffusion of macromolecules in a crowded environment.

Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations.

Vizardous: interactive analysis of microbial populations with single cell resolution.

Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level.

Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform.

Cutting the Gordian Knot: Identifiability of anaplerotic reactions in Corynebacterium glutamicum by means of (13) C-metabolic flux analysis.

(13)C Tracers for Glucose Degrading Pathway Discrimination in Gluconobacter oxydans 621H.

Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester.

Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression.

A scientific workflow framework for (13)C metabolic flux analysis.

Discrete-continuous reaction-diffusion model with mobile point-like sources and sinks.

Automation of a Nile red staining assay enables high throughput quantification of microalgal lipid production.

μMORE: A microfluidic magnetic oscillation reactor for accelerated parameter optimization in biocatalysis.

Design and validation of a parallelized micro-photobioreactor enabling phototrophic bioprocess development at elevated throughput.

Time-resolved, single-cell analysis of induced and programmed cell death via non-invasive propidium iodide and counterstain perfusion.

Metabolic profile of 1,5-diaminopentane producing Corynebacterium glutamicum under scale-down conditions: Blueprint for robustness to bioreactor inhomogeneities.

Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments.

A Toolbox of Genetically Encoded FRET-Based Biosensors for Rapid l-Lysine Analysis.

Use of a Sec signal peptide library from Bacillus subtilis for the optimization of cutinase secretion in Corynebacterium glutamicum.

Comparative evaluation of phototrophic microtiter plate cultivation against laboratory-scale photobioreactors.

A framework for accelerated phototrophic bioprocess development: integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design.

Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level.

Fast and reliable strain characterization of Streptomyces lividans through micro-scale cultivation.

Miniaturized and automated adaptive laboratory evolution: Evolving Corynebacterium glutamicum towards an improved d-xylose utilization.

Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity.

To be certain about the uncertainty: Bayesian statistics for 13 C metabolic flux analysis.

Corynebacterium glutamicum Chassis C1*: Building and Testing a Novel Platform Host for Synthetic Biology and Industrial Biotechnology.

pH fluctuations imperil the robustness of C. glutamicum to short term oxygen limitation.

Laboratory scale photobiotechnology - Current trends and future perspectives.

Automated growth rate determination in high-throughput microbioreactor systems.