Shioko Kimura

Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans.

A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma.

Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation.

Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice.

Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice.

Study of P450 function using gene knockout and transgenic mice.

Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.

Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles.

Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.

Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor.

[Homeodomain transcription factor T/EBP/NKX2.1 in development and differentiation of the thyroid and lung].

In vivo characterization of the Nkx2.1 promoter/enhancer elements in transgenic mice.

Thyrocyte-specific expression of Cre recombinase in transgenic mice.

Developmental regulation of claudin localization by fetal alveolar epithelial cells.

Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1.

Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9.

Progressive glomerulonephritis and histiocytic sarcoma associated with macrophage functional defects in CYP1B1-deficient mice.

An integrated regulatory network controlling survival and migration in thyroid organogenesis.

Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation.

Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.

Ventromedial hypothalamic nucleus-specific enhancer of Ad4BP/SF-1 gene.

A mouse model demonstrates a multigenic origin of congenital hypothyroidism.

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13.

Directed differentiation of neural cells to hypothalamic dopaminergic neurons.

Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid.

Alterations in skin and stratified epithelia by constitutively activated PPARalpha.

Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice.

A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes.

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.

Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid.

Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.

Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.

Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells.

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.

Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function.

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.

Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.

Side population cells in the mouse thyroid exhibit stem/progenitor cell-like characteristics.

Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma.

Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression.

Role of secretoglobin 3A2 in lung development.

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.

The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.

Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors.

Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.

IFN-gamma down-regulates Secretoglobin 3A1 gene expression.

Expression of secretoglobin3A2 (SCGB3A2) in primary pulmonary carcinomas.

Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.

The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells.

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.

Identification and characterization of rat RhoA gene promoter.

Development of thyroid gland and ultimobranchial body cyst is independent of p63.

A functional interaction between CPI-17 and RACK1 proteins in bronchial smooth muscle cells.

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.

FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo.

Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.

Experience dictates stem cell fate in the adult hippocampus.

Thyroid-specific transcription factors and their roles in thyroid cancer.

Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells.

Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function.

The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1.

Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity.

Thyroid regeneration: characterization of clear cells after partial thyroidectomy.

Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.

Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse.

Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.

Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs).

Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma.

Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis.

Stem cell antigen 1-positive mesenchymal cells are the origin of follicular cells during thyroid regeneration.

Molecular cloning and functional characterization of two forms of Pax8 in the rainbow trout, Oncorhynchus mykiss.

Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.

Thyroid regeneration: how stem cells play a role?

Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation.

Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.

Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells.

SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation.

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.

KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1.

Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.