Noninvasive Intratracheal Lipopolysaccharide Instillation in MicePeng Yu *1, Bo Lin *2, Jingyang Li 1, Yanqing Luo 1, Di Zhang 1, Jiayi Sun 1, Xianli Meng 1, Yingfan Hu 3, Li Xiang 1
1State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, 2Department of Pharmacy, The Second Affiliated Hospital of Hainan Medical University, 3The School of Preclinical Medicine, Chengdu University
Here, we propose a protocol for intratracheal lipopolysaccharide (LPS) delivery via noninvasive oropharyngeal endotracheal intubation. This method minimizes the trauma of the surgical procedure for the animal and accurately delivers LPS to the trachea and then to the lungs.
