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UCL Queen Square Institute of Neurology

3 ARTICLES PUBLISHED IN JoVE

Neuroscience

CMAP Scan MUNE (MScan) - A Novel Motor Unit Number Estimation (MUNE) Method

Anna B. Jacobsen¹, Hugh Bostock², Hatice Tankisi¹

¹Department of Clinical Neurophysiology, Aarhus University Hospital, ²Institute of Neurology, Queen Square House

This protocol describes a new method to estimate the number of functioning motor units in a muscle, by fitting a model to a detailed stimulus-response curve of the compound muscle action potential. It is quick and easy to perform and analyze and has excellent reproducibility.

Neuroscience

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Agnes Witt¹, Hugh Bostock², Werner J. Z'Graggen³, S. Veronica Tan⁴, Alexander Gramm Kristensen¹, Rikke Søgaard Kristensen¹, Lotte Hardbo Larsen¹, Zennia Zeppelin¹, Hatice Tankisi¹

¹Department of Clinical Neurophysiology, Aarhus University Hospital, ²UCL Queen Square Institute of Neurology, Queen Square House, ³Departments of Neurology and Neurosurgery, Inselspital, Bern University Hospital, University of Bern, ⁴MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery

Presented here is a protocol for the recording of muscle velocity recovery cycles (MVRCs), a new method of examining muscle membrane properties. MVRCs enable in vivo assessment of muscle membrane potential and alterations in muscle ion channel function in relation to pathology, and it enables the demonstration of muscle depolarization in neurogenic muscles.

Neuroscience

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Hatice Tankisi¹, James Howells², Bülent Cengiz³, Gintaute Samusyte⁴, Martin Koltzenburg⁵, Hugh Bostock⁶

¹Department of Clinical Neurophysiology, Aarhus University Hospital, ²Central Clinical School, Faculty of Medicine and Health, University of Sydney, ³Department of Neurology, Gazi University Faculty of Medicine, ⁴Department of Neurology, Medical Academy, Lithuanian University of Health Sciences, ⁵Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, ⁶Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology

We present a suite of standardized single- and paired-pulse transcranial magnetic stimulation (TMS) recording protocols, with options for conventional amplitude measurements and threshold-tracking. This program can control three different types of magnetic stimulators and is designed to enable all tests to be performed conveniently by a single operator.