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Fox Chase Cancer Center

3 ARTICLES PUBLISHED IN JoVE

Medicine

An in vivo Assay to Test Blood Vessel Permeability

We are presenting an in vivo assay to test blood vessel permeability. This assay is based on intravenous injection of a dye and subsequent visualization of its diffusion into interstitial spaces.

Medicine

Minimal Erythema Dose (MED) Testing

Carolyn J. Heckman¹, Rachel Chandler², Jacqueline D. Kloss³, Amy Benson², Deborah Rooney², Teja Munshi¹, Susan D. Darlow¹, Clifford Perlis⁴, Sharon L. Manne⁵, David W. Oslin²

¹Cancer Prevention and Control Program, Fox Chase Cancer Center , ²Department of Psychiatry, University of Pennsylvania , ³Department of Psychology, Drexel University , ⁴Department of Medicine, Fox Chase Cancer Center , ⁵Cancer Prevention and Control Program, The Cancer Institute of New Jersey

This article describes how to conduct minimal erythema dose (MED) testing in order to determine the lowest dose of ultraviolet radiation that will cause erythema (burning) when administered to an individual.

Biochemistry

Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay

Sofiia Karchugina¹, Jonathan Chernoff¹

¹Fox Chase Cancer Center

Here, we show how to use a Proximity Ligation Assay (PLA) to visualize MST1/MST2 heterodimerization in fixed cells with high sensitivity.