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UCL Institute of Child Health and Great Ormond Street Hospital

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

A Decellularization Methodology for the Production of a Natural Acellular Intestinal Matrix

Panagiotis Maghsoudlou^*1, Giorgia Totonelli^*1, Stavros P Loukogeorgakis¹, Simon Eaton¹, Paolo De Coppi¹

¹Surgery Unit, Institute of Child Health and Great Ormond Street Hospital, University College London

The article describes a methodology for the production of an acellular matrix from rat intestine. The derivation of intestinal scaffolds is important for future applications in tissue engineering, stem cell biology and drug testing.

Developmental Biology

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System

Enrica Bertin¹, Martina Piccoli¹, Chiara Franzin¹, Andras Nagy², Maria Mileikovsky², Paolo De Coppi³, Michela Pozzobon¹

¹Stem Cell and Regenerative Medicine Laboratory, Fondazione Istituto di Ricerca Pediatrica Citta della Speranza, ²Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, ³Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Programme, UCL Institute of Child Health and Great Ormond Street Hospital

In this study, we generate induced pluripotent stem cells from mouse amniotic fluid cells, using a non-viral-based transposon system.