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Chang-Gung University College of Medicine

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Murine Full-thickness Skin Transplantation

Chih-Hsien Cheng^*1,2, Chen-Fang Lee^*1,2, Madeline Fryer^*3, Georg J. Furtmüller³, Byoungchol Oh³, Jonathan D. Powell¹, Gerald Brandacher³

¹Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, ²Department of Liver and Transplantation Surgery, Chang-Gung Transplantation Institute, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, ³Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine

Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.

Medicine

Ex Vivo and In Vivo Animal Models for Mechanical and Chemical Injuries of Corneal Epithelium

Kuo Hsuan Hung^1,2,3, Lung Kun Yeh^1,2

¹Department of Ophthalmology, Chang-Gung Memorial Hospital, ²Chang-Gung University College of Medicine, ³Institute of Clinical Medicine, National Yang Ming Chiao Tung University

Here, animal models based on mouse and rabbit are developed for mechanical and chemical injury of corneal epithelium to screen new therapeutics and the underlying mechanism.