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British Columbia Children's Hospital & University of British Columbia

1 ARTICLES PUBLISHED IN JoVE

JoVE Journal

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Shaun Pacheco¹, Shan-Yu Fung², Mingyao Liu^1,3

¹Latner Thoracic Surgery Research Laboratories, University Health Network, ²Department of Pediatrics, British Columbia Children's Hospital & University of British Columbia, ³Institute of Medical Science, University of Toronto

This protocol describes a clinically-applicable means of dissolving hydrophobic compounds in an aqueous environment using combinations of self-assembling peptide and amino acid solutions. Our method resolves a major limitation of hydrophobic therapeutics, which lack safe, efficient means of solubility and delivery methods into clinical settings.