JoVE Journal

Medicine

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

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05:08 min

September 20th, 2017

September 20th, 2017

16,394 Views

0:05

Title

0:37

Preparation of Amino Acid Solutions

1:16

Preparation of SAP-AA Solutions

1:56

Preparation of Drug-DMSO or Drug-Ethanol Stock Solutions and Drug Formulations

3:11

Solubility Testing

3:36

Results: Enhancement of Hydrophobic Compound Solubility in Aqueous Solution with Self-assembling Peptide and Amino Acid Solutions

4:16

Conclusion

文字起こし

The overall goal of this method is to increase solubility of hydrophobic compounds in aqueous solution for potential delivery into clinical settings. This method addresses a key limitation in the medical field which is a lack of use of hydrophobic

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This protocol describes a clinically-applicable means of dissolving hydrophobic compounds in an aqueous environment using combinations of self-assembling peptide and amino acid solutions. Our method resolves a major limitation of hydrophobic therapeutics, which lack safe, efficient means of solubility and delivery methods into clinical settings.

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