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BioMarin Pharmaceutical Inc

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Ruby Cheung¹, Gregory W. deHart¹, Lynne Jesaitis¹, Stephen J. Zoog¹, Andrew C. Melton¹

Here we present a cell-based flow cytometry method to detect neutralizing antibodies or other factors that interfere with the cellular uptake of enzyme replacement therapies in a human matrix, such as cerebral spinal fluid (CSF) or human serum.