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BioMarin Pharmaceutical Inc

1 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
Ruby Cheung 1, Gregory W. deHart 1, Lynne Jesaitis 1, Stephen J. Zoog 1, Andrew C. Melton 1
1BioMarin Pharmaceutical Inc

Here we present a cell-based flow cytometry method to detect neutralizing antibodies or other factors that interfere with the cellular uptake of enzyme replacement therapies in a human matrix, such as cerebral spinal fluid (CSF) or human serum.

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