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Mackay Medical College

4 ARTICLES PUBLISHED IN JoVE

Medicine

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Chun-Nin Lee¹, Li-Hsuan Chiu^2,5, Chia-Lang Fang³, Shauh-Der Yeh⁴, Chun S. Zuo⁵, Shih-Ching Chen⁶, Li-Kuo Kuo⁷, Yun-Ming Wang⁸, Wen-Fu Thomas Lai^2,5,9

¹Department of Pulmonary and Critical Care Medicine, Taipei Medical University-Shuang Ho Hospital, ²Department of Research and Department of Dentistry, Taipei Medical University / Shuang-Ho Hospital, ³Department of Pathology, Taipei Medical University, ⁴Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, ⁵McLean Imaging Center, McLean Hospital/Harvard Medical School, ⁶Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, ⁷Department of Medicine, Mackay Medical College, ⁸Department of Biological Science and Technology, National Chiao Tung University, ⁹Graduate Institute of Clinical Medicine, Taipei Medical University

To improve serological diagnostic tests for Mycobacterium tuberculosis antigens, we developed superparamagnetic iron oxide nanoprobes to detect extrapulmonary tuberculosis.

Medicine

An Endoscopic Transcanal Transpromontorial Approach for Vestibular Schwannomas using a Computer-Based Three-Dimensional Imaging System

Chin-Kuo Chen¹, Li-Chun Hsieh^2,3, Yu-Jen Lu⁴, Chu-Po Lin⁵

¹Department of Otolaryngology-Head and Neck Surgery and Communication Enhancement Center, Chang Gung Memorial Hospital and Chang Gung University, ²Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, ³Department of Audiology and Speech Language Pathology, Mackay Medical College, ⁴Department of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University, ⁵Department of Medical Education, Chang Gung Memorial Hospital and Chang Gung University

Here, we present a transcanal transpromontorial approach for vestibular schwannomas using a computer-based three-dimensional (3D) imaging system combined with a two-dimensional (2D) endoscope. This system provided stereoscopic vision, better depth perception and reduced visual fatigue. This 3D imaging system enabled the application of 3D vision technology in endoscopic lateral skull base surgery.

Medicine

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Hui-Chun Ku¹, Ding-Kuo Chien^2,3,4,5, Chuan-Lei Chao^5,6, Shih-Yi Lee^5,7

¹Department of Life Science, Fu Jen Catholic University, ²Department of Medicine, MacKay Medical College, ³Department of Emergency Medicine, MacKay Memorial Hospital, ⁴Graduate Institute of Injury Prevention and Control, Taipei Medical University, ⁵MacKay Junior College of Medicine, Nursing, and Management, ⁶Division of Cardiology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, ⁷Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, MacKay Memorial Hospital

Herein, we present a protocol focusing on the quality control of the left anterior descending coronary artery ligation by technically modifying the traditional procedure in rats for acute myocardial ischemia-reperfusion research.

Neuroscience

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Dian-Shiue Lee¹, Yu-Ling Pan¹, Yi-Chao Hsu^1,2

¹Department of Audiology and Speech-Language Pathology, MacKay Medical College, ²Institute of Biomedical Sciences, MacKay Medical College

Here, we present a protocol for a mouse model of noise-induced hearing loss (NIHL). To induce NIHL, we developed a new and simple device using corrugated plastic, a rat trap cage, and a speaker. Auditory brainstem response and immunofluorescence imaging were employed to assess the hearing function and outer hair cell damage, respectively.