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Chapter 1

Pharmacokinetics and Pharmacodynamics: Introduction

バイオ医薬品学と薬物動態学:概要
バイオ医薬品学と薬物動態学:概要
Drugs come in various dosage forms, including solids, liquids, semisolids, or aerosols. These formulations deliver drugs at the site of action, triggering ...
薬物動態モデル:概要
薬物動態モデル:概要
Pharmacokinetic models use mathematical analysis to express a drug's time course in the body. These models can simulate rates of a drug's ...
薬物濃度と時間相関
薬物濃度と時間相関
Plasma drug levels, plotted at regular intervals, help track its time course in the body. For instance, consider a plot after a single oral dose. The drug ...
薬物濃度:測定
薬物濃度:測定
Drug concentration represents the drug amount present in a biological sample. It helps assess the initial drug pharmacokinetics in the body. The samples ...
薬物動態学における基本的な数学的原理:微積分学とグラフ
薬物動態学における基本的な数学的原理:微積分学とグラフ
Pharmacokinetic models view drugs within the body as dynamic entities and rely on calculus as a vital tool for quantitative drug movement analysis. ...
薬物動態学における基本的な数学的原理:数式と単位
薬物動態学における基本的な数学的原理:数式と単位
Mathematical expressions help understand pharmacokinetic parameters by using equations to describe the relationships between different variables. For ...
薬物動態学における基本的な数学的原理:反応の速度と順序
薬物動態学における基本的な数学的原理:反応の速度と順序
Pharmacokinetic models incorporate reaction order and rate to comprehend processes such as drug absorption and elimination. In pharmacokinetics, the rate ...
母集団薬物動態データの分析
母集団薬物動態データの分析
Traditional pharmacokinetic methods involve taking multiple samples from a few individuals and estimating pharmacokinetic parameters. Despite their common ...
薬力学:概要と原理
薬力学:概要と原理
Pharmacodynamics is the scientific study that explores the biochemical, cellular, and physiological effects of drugs on the body. Most drug effects result ...
構造活性相関と創薬
構造活性相関と創薬
Drug design involves discovering new medications based on specific biological targets. It relies on structure-activity relationships, SAR, or quantitative ...
アゴニズムとアンタゴニズム:定量化
アゴニズムとアンタゴニズム:定量化
Administration of drugs can lead to either agonist or antagonist effect. Agonism occurs when a drug activates a receptor, triggering a biological ...
薬物管理ガバナンス:規制機関とその影響
薬物管理ガバナンス:規制機関とその影響
Drug control governance involves global regulatory bodies that standardize and control the safety and efficacy of pharmaceuticals, as well as prevent ...
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