Patricia B. Hoyer

17beta-estradiol affords protection against 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in Fischer-344 rats.

mdr1a deficiency corrects sterility in Niemann-Pick C1 protein deficient female mice.

Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries.

In vitro ovarian tissue and organ culture: a review.

Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats.

Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide.

Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide.

Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.

The follicle-deplete mouse ovary produces androgen.

Can the clock be turned back on ovarian aging?

Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinylcyclohexene diepoxide.

Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss.

Damage to ovarian development and function.

Atherosclerotic lesion development in a novel ovary-intact mouse model of perimenopause.

Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause.

Effect of bcl-2 overexpression in mice on ovotoxicity caused by 4-vinylcyclohexene.

Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause.

Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition.

Dual modality imaging of a novel rat model of ovarian carcinogenesis.

NTP-CERHR expert panel report on the reproductive and developmental toxicity of soy formula.

NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein.

involvement of microsomal epoxide hydrolase enzyme in ovotoxicity caused by 7,12-dimethylbenz[a]anthracene.

BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries.

Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study.

Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause.

Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse.

Involvement of CYP 2E1 enzyme in ovotoxicity caused by 4-vinylcyclohexene and its metabolites.

Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis).

Effects of impending ovarian failure induced by 4-vinylcyclohexene diepoxide on fertility in C57BL/6 female mice.

Drinking water with uranium below the U.S. EPA water standard causes estrogen receptor-dependent responses in female mice.

Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice.

Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice.

Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats.

Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure.

Steroidogenic capacity of residual ovarian tissue in 4-vinylcyclohexene diepoxide-treated mice.

Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system.

Serum antimüllerian hormone predicts ovarian reserve in a monkey model.

Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes.

Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome.

Current methods in investigating the development of the female reproductive system.

Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.

7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide.

The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis).

Dual protective role for glutathione S-transferase class pi against VCD-induced ovotoxicity in the rat ovary.

Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity.

Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice.

A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity.

Midkine, a heparin-binding protein, is increased in the diabetic mouse kidney postmenopause.

Inhibition of PIK3 signaling pathway members by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.

Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis.

Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis).

Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53.

4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats.

Inhibition of ovarian KIT phosphorylation by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.

Xenobiotic effects on ovarian preantral follicles.

Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling.

4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity.

Modeling perimenopause in Sprague-Dawley rats by chemical manipulation of the transition to ovarian failure.

Analysis of second-harmonic-generation microscopy in a mouse model of ovarian carcinoma.

Glutathione S-transferase class μ regulation of apoptosis signal-regulating kinase 1 protein during VCD-induced ovotoxicity in neonatal rat ovaries.

Two-photon excited fluorescence imaging of endogenous contrast in a mouse model of ovarian cancer.

Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes.

7,12-dimethylbenz[a]anthracene-induced malignancies in a mouse model of menopause.

In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis.

Xenobiotic effects in the ovary: temporary versus permanent infertility.

Acute 7,12-dimethylbenz[a]anthracene exposure causes differential concentration-dependent follicle depletion and gene expression in neonatal rat ovaries.

Involvement of a volatile metabolite during phosphoramide mustard-induced ovotoxicity.