Department of Pharmacology,
Department of Cellular and Molecular Physiology
Leonard K. Kaczmarek has not added Biography.
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Protein kinase modulation of a neuronal cation channel requires protein-protein interactions mediated by an Src homology 3 domain.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2002 | Pubmed ID: 11756482
Endogenous parathyroid hormone-related protein functions as a neuroprotective agent.
Brain research Mar, 2002 | Pubmed ID: 11879796
HSV-1 helper virus 5dl1.2 suppresses sodium currents in amplicon-transduced neurons.
Journal of neurophysiology Apr, 2002 | Pubmed ID: 11929932
Localization of the Slack potassium channel in the rat central nervous system.
The Journal of comparative neurology Dec, 2002 | Pubmed ID: 12442315
Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2002 | Pubmed ID: 12451114
Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2003 | Pubmed ID: 12598601
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development.
Developmental cell Apr, 2003 | Pubmed ID: 12689595
Modulation of mitochondrial function by endogenous Zn2+ pools.
Proceedings of the National Academy of Sciences of the United States of America May, 2003 | Pubmed ID: 12724524
Compensatory anion currents in Kv1.3 channel-deficient thymocytes.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12878608
Modulation of synaptic transmission by the BCL-2 family protein BCL-xL.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2003 | Pubmed ID: 12968005
How to make a relationship last: release sites with different levels of commitment.
Neuron Sep, 2003 | Pubmed ID: 14527428
Functional specialization of male and female vocal motoneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2003 | Pubmed ID: 14684859
Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2003 | Pubmed ID: 14684870
The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 14981264
Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2004 | Pubmed ID: 14985434
Act locally: new ways of regulating voltage-gated ion channels.
Molecular interventions Jul, 2002 | Pubmed ID: 14993392
Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia.
Journal of neurobiology Sep, 2004 | Pubmed ID: 15307146
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2004 | Pubmed ID: 15342906
The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15375169
Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies.
Journal of neurobiology Mar, 2005 | Pubmed ID: 15547932
Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse.
The Journal of biological chemistry Feb, 2005 | Pubmed ID: 15561723
Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.
Science (New York, N.Y.) Jan, 2005 | Pubmed ID: 15637280
Localization of the Na+-activated K+ channel Slick in the rat central nervous system.
The Journal of comparative neurology Mar, 2005 | Pubmed ID: 15717307
For K+ channels, Na+ is the new Ca2+.
Trends in neurosciences Aug, 2005 | Pubmed ID: 15979166
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.
Hearing research Aug, 2005 | Pubmed ID: 16081004
Actions of BAX on mitochondrial channel activity and on synaptic transmission.
Antioxidants & redox signaling Sep-Oct, 2005 | Pubmed ID: 16115013
Association/dissociation of a channel-kinase complex underlies state-dependent modulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2005 | Pubmed ID: 16135761
Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons.
Nature neuroscience Oct, 2005 | Pubmed ID: 16136041
Retraction.
Science (New York, N.Y.) Dec, 2005 | Pubmed ID: 16373558
Policing the ball: a new potassium channel subunit determines inactivation rate.
Neuron Mar, 2006 | Pubmed ID: 16504937
Modulation of Kv3.1b potassium channel phosphorylation in auditory neurons by conventional and novel protein kinase C isozymes.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16595659
Opposite regulation of Slick and Slack K+ channels by neuromodulators.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2006 | Pubmed ID: 16687497
Pharmacological activation and inhibition of Slack (Slo2.2) channels.
Neuropharmacology Sep, 2006 | Pubmed ID: 16876206
A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia.
Journal of neurophysiology Nov, 2006 | Pubmed ID: 16885525
Non-conducting functions of voltage-gated ion channels.
Nature reviews. Neuroscience Oct, 2006 | Pubmed ID: 16988652
Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia.
Neurogenetics Apr, 2007 | Pubmed ID: 17136396
Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2007 | Pubmed ID: 17344399
Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons.
The Journal of physiology Nov, 2007 | Pubmed ID: 17884929
Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons.
Biochemical and biophysical research communications Feb, 2008 | Pubmed ID: 18053804
Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.
Journal of neurophysiology Mar, 2008 | Pubmed ID: 18160428
Repetitive firing triggers clustering of Kv2.1 potassium channels in Aplysia neurons.
The Journal of biological chemistry Apr, 2008 | Pubmed ID: 18276591
PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2008 | Pubmed ID: 18322103
Protein kinase C modulates inactivation of Kv3.3 channels.
The Journal of biological chemistry Aug, 2008 | Pubmed ID: 18539595
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
The Journal of physiology Nov, 2008 | Pubmed ID: 18787033
Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19095801
The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2009 | Pubmed ID: 19403831
Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors.
Journal of receptor and signal transduction research , 2009 | Pubmed ID: 19640220
Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.
The Journal of physiology May, 2010 | Pubmed ID: 20308249
The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice.
Journal of neurophysiology Jun, 2010 | Pubmed ID: 20393063
Controlling auditory excitability: the benefits of a cultured environment.
The Journal of physiology May, 2010 | Pubmed ID: 20436041
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.
Nature neuroscience Jul, 2010 | Pubmed ID: 20512134
Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.
The Journal of comparative neurology Aug, 2010 | Pubmed ID: 20575068
A less flexible BK channel opens more easily.
Neuron Jun, 2010 | Pubmed ID: 20620867
Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2010 | Pubmed ID: 20685971
Potassium channel modulation and auditory processing.
Hearing research Sep, 2011 | Pubmed ID: 21414395
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.
The Journal of cell biology Oct, 2011 | Pubmed ID: 21987637
Gradients and modulation of K(+) channels optimize temporal accuracy in networks of auditory neurons.
PLoS computational biology , 2012 | Pubmed ID: 22438799
De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy.
Nature genetics Nov, 2012 | Pubmed ID: 23086397
Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2012 | Pubmed ID: 23115170
An evolutionarily conserved mode of modulation of Shaw-like K⺠channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2013 | Pubmed ID: 23233530
A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude.
Journal of neurophysiology Apr, 2013 | Pubmed ID: 23324315
Expression of Kv1.3 potassium channels regulates density of cortical interneurons.
Developmental neurobiology Nov, 2013 | Pubmed ID: 23821603
Slack, Slick and Sodium-Activated Potassium Channels.
ISRN neuroscience Apr, 2013 | Pubmed ID: 24319675
The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments.
Frontiers in cellular neuroscience , 2013 | Pubmed ID: 24368895
Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis.
Human molecular genetics Jan, 2014 | Pubmed ID: 24463883
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